{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T09:50:59Z","timestamp":1765878659550,"version":"3.48.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["401000312"],"award-info":[{"award-number":["401000312"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Exposure to extremely low\u2010frequency magnetic fields (ELF\u2010MFs) has increased with technological development. Environmental factors are known to influence the K\n                      <jats:sup>+<\/jats:sup>\n                      \u2013Cl\n                      <jats:sup>\u2212<\/jats:sup>\n                      cotransporter 2 (KCC2), which regulates neuronal chloride homeostasis and is essential for brain development through its role in the GABAergic shift. In this study, we investigated the effects of ELF\u2010MF exposure on KCC2 expression and related behavioral and biochemical outcomes in Wistar rat pups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Wistar rat pups were exposed to ELF\u2010MF (10\u2009mT, 50\u2009Hz) for 2\u2009h per day from postnatal day (PND) 1 to 10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results indicated a significant reduction in KCC2 expression in the ELF\u2010MF\u2013exposed group. Furthermore, these animals exhibited enhanced anxiety\u2010like behaviors, elevated brain malondialdehyde (MDA) levels, and shortened latency to tonic\u2013clonic seizures compared with controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that early exposure to ELF\u2010MFs disrupts KCC2 expression in the developing brain and induces behavioral and biochemical abnormalities in male rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.2546","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:21:03Z","timestamp":1762852863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression Pattern Alterations of the Brain\n                    <scp>KCC2<\/scp>\n                    Chloride Transporter in Male Rats Following Postnatal Extremely Low\u2010Frequency Electromagnetic Field Exposure Associated With Behavioral Outcomes"],"prefix":"10.1002","volume":"117","author":[{"given":"Mozhdeh","family":"Nemati","sequence":"first","affiliation":[{"name":"Student Research Committee Kerman University of Medical Sciences  Kerman Iran"},{"name":"Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1543-6240","authenticated-orcid":false,"given":"Masoumeh","family":"Nozari","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Darvishzadeh\u2010Mahani","sequence":"additional","affiliation":[{"name":"Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meysam","family":"Ahmadi\u2010Zeidabadi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepideh","family":"Ganjalikhan\u2010hakemi","sequence":"additional","affiliation":[{"name":"Student Research Committee Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamideh","family":"Bashiri","sequence":"additional","affiliation":[{"name":"Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Haratizadeh","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Faculty of Medicine Mashhad 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