{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:19:00Z","timestamp":1766999940160,"version":"3.48.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["NIEHS R01 ES026317"],"award-info":[{"award-number":["NIEHS R01 ES026317"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R21 ES030784"],"award-info":[{"award-number":["R21 ES030784"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30 ES000002"],"award-info":[{"award-number":["P30 ES000002"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["NICHD P50 HD105351"],"award-info":[{"award-number":["NICHD P50 HD105351"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R13 HD100191"],"award-info":[{"award-number":["R13 HD100191"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neural tube defects such as spina bifida (SB) are congenital anomalies associated with significant morbidity and mortality worldwide. Environmental factors, particularly folate, modify SB risk. Based on recurrence rates of SB within families, genetic risk also contributes to SB development. However, the effect of maternal folate intake on genetic risk for SB in Bangladesh has not been quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genetic variants were imputed from array data of 112 infants with SB and 116 infants without SB. After quality filtering, genome\u2010wide association was performed on 91 infants with SB and 97 without. Maternal folate intake and maternal nail arsenic concentration were included as covariates and interaction terms (SNP \u00d7 Folate, SNP \u00d7 Arsenic) along with maternal age, infant sex, and 10 principal components as covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two loci had variants nominally associated with SB: one within the coding region of\n                      <jats:italic>WWOX<\/jats:italic>\n                      , including rs7184417 (odds ratio [OR]\u2009=\u20096.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20092.22E\u201006), and a second in the coding region of\n                      <jats:italic>ISOC2<\/jats:italic>\n                      (rs4801638; OR\u2009=\u20090.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20095.75E\u201006). With the gene\u2010folate interaction, a locus in\n                      <jats:italic>CNTN5<\/jats:italic>\n                      was associated with SB. After including the gene\u2010arsenic interaction, the gene\u2010folate interaction effect was nominally associated with a locus in\n                      <jats:italic>CTNNA2<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inclusion of maternal folate intake as a covariate and interaction term identified three genomic loci that could impact the risk for SB. A fourth locus was identified when maternal arsenic level was included. These nominal associations should be assessed in additional cohorts with larger sample sizes. Novel genes impacted by these loci may interact with previously reported genes for SB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.70007","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:20:03Z","timestamp":1765455603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Folate Interaction With Genetic Risk for Neural Tube Defects Among Infants in Bangladesh"],"prefix":"10.1002","volume":"117","author":[{"given":"Enrique","family":"Mondragon\u2010Estrada","sequence":"first","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Fetal Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Uhler","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Fetal Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afifah","family":"Farooque","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudipta Kumer","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurosurgery National Institute of Neurosciences and Hospital (NINS&amp;H)  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheikh Muhammad","family":"Ekramullah","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurosurgery National Institute of Neurosciences and Hospital (NINS&amp;H)  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Arman","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurosurgery National Institute of Neurosciences and Hospital (NINS&amp;H)  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joynul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosurgery National Institute of Neurosciences and Hospital (NINS)  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiza Sultana","family":"Suchanda","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Research Committee National Institute of Neurosciences and Hospital (NINS)  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Christiani","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin C.","family":"Warf","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Neurosurgery Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maitreyi","family":"Mazumdar","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Neurology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7816-2646","authenticated-orcid":false,"given":"Sarah U.","family":"Morton","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Fetal Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1380"},{"key":"e_1_2_10_3_1","unstructured":"Browning B. 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