{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:00:10Z","timestamp":1787500810760,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                      <\/jats:styled-content>\n                      (CT) diagnoses are highest among females of reproductive age. Yet, little is known about adverse infant outcomes associated with treatment for CT infections during pregnancy, including birth defects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using de\u2010identified matched data from the New York State (NYS) Sexually Transmitted Infection Surveillance Registry and live births reported to the NYS Birth Defects Registry from 2010 to 2020, we conducted a retrospective cohort study among pregnancies with one first\u2010trimester CT diagnosis to assess the impact of adequate CT treatment on the risk of selected birth defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pregnancies with evidence of adequate CT treatment during the first trimester were more likely (adjusted risk ratio [ARR]: 3.0, 95% confidence interval [CI]: 1.7\u20135.2) to have an infant with at least one selected birth defect. This association was attenuated in sensitivity analyses including pregnancies with evidence of adequate treatment any time during pregnancy (ARR: 1.2, 95% CI: 0.7\u20132.1) and evidence of adequate treatment through the second trimester (ARR: 1.9, 95% CI: 0.8\u20134.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results did not support the hypothesis that adequate first\u2010trimester CT treatment was associated with a decreased risk of selected birth defects. However, additional investigation is warranted to understand if an association is driven by the timing of infection or treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.70012","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:49:41Z","timestamp":1768884581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Chlamydia Treatment During Pregnancy on\u00a0Birth Defects in New York State"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-4136","authenticated-orcid":false,"given":"Elizabeth M.","family":"Boos","sequence":"first","affiliation":[{"name":"College of Integrated Health Sciences University at Albany  Albany New York USA"},{"name":"New York State Department of Health AIDS Institute  Albany New York USA"},{"name":"Center for Collaborative HIV Research in Practice and Policy, College of Integrated Health Sciences University at Albany  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-5040","authenticated-orcid":false,"given":"Meredith","family":"Howley","sequence":"additional","affiliation":[{"name":"College of Integrated Health Sciences University at Albany  Albany New York USA"},{"name":"Center for Environmental Health New York State Department of Health  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Udo","sequence":"additional","affiliation":[{"name":"College of Integrated Health Sciences University at Albany  Albany New York USA"},{"name":"Center for Collaborative HIV Research in Practice and Policy, College of Integrated Health Sciences University at Albany  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Miranda","sequence":"additional","affiliation":[{"name":"New York State Department of Health AIDS Institute  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"New York State Department of Health AIDS Institute  Albany New York USA"},{"name":"Center for Collaborative HIV Research in Practice and Policy, College of Integrated Health Sciences University at Albany  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Hart\u2010Malloy","sequence":"additional","affiliation":[{"name":"College of Integrated Health Sciences University at Albany  Albany New York USA"},{"name":"New York State Department of Health AIDS Institute  Albany New York USA"},{"name":"Center for Collaborative HIV Research in Practice and Policy, College of Integrated Health Sciences University at Albany  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2023.02.010"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20749"},{"key":"e_1_2_14_4_1","unstructured":"Centers for Disease Control and Prevention.2024a.\u201cAbout Chlamydia.\u201dRetrieved January 25 fromhttps:\/\/www.cdc.gov\/std\/chlamydia\/stdfact\u2010chlamydia.htm; 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