{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T15:36:34Z","timestamp":1776958594992,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Small intestinal atresia (SIA) consists of a congenital obstruction of the lumen of the duodenum, jejunum, or ileum with varying severity. The aim of the investigation was to analyze the prevalence and mortality of SIA, using data from the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data on SIA cases were collected from 25 ICBDSR members' surveillance programs in 17 countries over 1974\u20132015. All pregnancy outcomes were included, but terminations of pregnancy were not available for 11 programs. Statistical analysis is descriptive, and the prevalence is established by the total of SIA cases divided by the total of births. The survival time was calculated, and mortality was analyzed individually using the Kaplan\u2013Meier method for comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The total prevalence of SIA was 2.1 per 10,000 births. Iran had the highest prevalence with 11.5 per 10,000 total births (95% CI: 9\u201314.1); on the other hand, the lowest prevalence of SIA was in Mexico\u2010Nuevo Leon with 0.5 per 10,000 births (95% CI: 0.3\u20130.8), and Cali\u2010Colombia had zero cases. In South America, a higher prevalence of SIA was estimated compared to what was reported in 2000. Most deaths occurred between Day 2 and 6, except in Bogot\u00e1\u2010Colombia, Spain, UK\u2010Wales, and Mexico, where the deaths occurred on Day 1. The mortality in the first year was 4.3%, but the specific causes of death were not determined in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of SIA was about 2.1 per 10,000 births during a 41\u2010year period in 25 centers, with variations in prevalence according to geographical locations. Future research is suggested to analyze changes in trends and the impact of early diagnosis and treatment in mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.70032","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:34:34Z","timestamp":1776688474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Prevalence and Mortality Among Neonates and Children With Intestinal Atresia: A Multinational Study, 1974\u20132015"],"prefix":"10.1002","volume":"118","author":[{"given":"Angie","family":"Carre\u00f1o","sequence":"first","affiliation":[{"name":"Birth Defect Surveillance Program, Faculty of Health Sciences Pontificia Universidad Javeriana  Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paula","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Human Genetics Institute, Faculty of Medicine Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2367-2320","authenticated-orcid":false,"given":"Lina","family":"Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Universidad Libre Sectional Cali  Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-8402","authenticated-orcid":false,"given":"Karen","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"Department of Physiologic Science, Faculty of Medicine Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-0776","authenticated-orcid":false,"given":"Juan A.","family":"Gili","sequence":"additional","affiliation":[{"name":"Latin American Collaborative Study of Congenital Malformations (ECLAMC), Center for Medical Education and Clinical Research (CEMIC\u2010CONICET)  Buenos Aires Argentina"},{"name":"National University of Villa Mar\u00eda  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Siffel","sequence":"additional","affiliation":[{"name":"College of Allied Health Sciences, Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy N.","family":"Nembhard","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention and Arkansas Reproductive Health Monitoring System, University of Arkansas for Medical Sciences, Department of Epidemiology  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-3619","authenticated-orcid":false,"given":"Jorieke E. H.","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Genetics EUROCAT Northern Netherlands, University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Bermejo\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"ECEMC (Spanish Collaborative Study of Congenital Malformations), UIAC (Research Center on Congenital Anomalies) Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"Lombardy Congenital Anomalies Registry, Cancer Registry Unit, Fondazione IRCCS, National Cancer Institute  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Dastgiri","sequence":"additional","affiliation":[{"name":"Health Services Management Research Centre, Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9171-7848","authenticated-orcid":false,"given":"Marcia L.","family":"Feldkamp","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Pocius","sequence":"additional","affiliation":[{"name":"Utah Birth Defect Network, Office of Children With Special Health Care Needs, Division of Family Health, Utah Department of Health and Human Services  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Gatt","sequence":"additional","affiliation":[{"name":"Malta Congenital Anomalies Registry, Directorate for Health Information and Research  La Valeta Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Genetics Department University Hospital Dr. Jos\u00e9 E. Gonz\u00e1lez, Autonomous University of Nuevo Le\u00f3n  Nuevo Le\u00f3n Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Aurora","family":"Canessa","sequence":"additional","affiliation":[{"name":"Regional Register Congenital Malformation Maule Health Service (RRMC\u2010SSM)  Maule Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6263-2562","authenticated-orcid":false,"given":"Boris","family":"Groisman","sequence":"additional","affiliation":[{"name":"National Network of Congenital Anomalies of Argentina (RENAC), National Center of Medical Genetics, National Administration of Laboratories and Health Institutes (ANLIS), National Ministry of Health and Social Development  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"K\u00e4ll\u00e9n","sequence":"additional","affiliation":[{"name":"National Board of Health and Welfare  Stockholm 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Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2014.09.017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102011\u2010300631"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102019\u2010317085"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500471"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010010\u20102729\u20108"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010017\u20104120\u20105"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010004\u20101152\u20104"},{"key":"e_1_2_11_9_1","unstructured":"England Public Health.2019.\u201cNational Congenital Anomaly and Rare Disease Registration Service (NCARDRS): Congenital Anomalies Statistics 2019: Tables.\u201dhttps:\/\/www.gov.uk\/government\/publications\/ncardrs\u2010congenital\u2010anomaly\u2010annual\u2010data."},{"key":"e_1_2_11_10_1","unstructured":"Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC). n.d.History.http:\/\/www.eclamc.org\/historia.html."},{"key":"e_1_2_11_11_1","unstructured":"European Platform on Rare Disease Registration (EUROCAT).2019.\u201cPrevalence Charts and Tables\u2014Prevalence 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