{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:31:16Z","timestamp":1786627876913,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Little is known about routine testing practices and diagnosis of congenital cytomegalovirus (cCMV) infection in newborns admitted to neonatal intensive care units (NICUs) across the United States. We assessed demographics and clinical signs associated with cCMV testing and diagnosis in newborns admitted to US NICUs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed Pediatrix Clinical Data Warehouse data, comprising 840,988 newborns admitted to 389 NICUs in 35 states during 2010\u20132020. We defined cCMV testing as culture or PCR performed on urine, saliva, blood, or cerebrospinal fluid collected within 21\u2009days of life, and a positive result (except in saliva) as cCMV infection diagnosis. Logistic regression models examined associations between clinical signs and cCMV testing and diagnosis separately, adjusting for region, birth year, and prematurity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 10,033 (1.2%) newborns tested (67.7% by culture; 79.8% using urine), 559 (5.6%) were diagnosed with cCMV infection. During 2010\u20132020, among those tested, the proportion with \u2264\u20091 clinical sign increased from 12.9% to 32.0%. Hepatosplenomegaly, petechiae, microcephaly, hepatitis, thrombocytopenia, chorioretinitis, and intracranial calcifications were associated with increased odds of both cCMV testing and diagnosis, with varying specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite low CMV testing rates in the NICU, a shift toward testing newborns with fewer clinical signs occurred over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.70092","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:02:47Z","timestamp":1784800967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Congenital Cytomegalovirus Among Newborns in Neonatal Intensive Care Units, United States, 2010\u20132020"],"prefix":"10.1002","volume":"118","author":[{"given":"Kelley","family":"Raines","sequence":"first","affiliation":[{"name":"Division of Viral Diseases National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashrita","family":"Rau","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reese","family":"Clark","sequence":"additional","affiliation":[{"name":"The Center for Research, Education, and Quality Improvement, Pediatrix Medical Group  Sunrise Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9343-3355","authenticated-orcid":false,"given":"Kate R.","family":"Woodworth","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van T.","family":"Tong","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sugerman","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2499-4786","authenticated-orcid":false,"given":"Tatiana M.","family":"Lanzieri","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Red Book 2021: Report of the Committee on Infectious Diseases","author":"American Academy of Pediatrics Committee on Infectious Diseases","year":"2021"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.423"},{"key":"e_1_2_12_4_1","volume-title":"Newborn Screening for Congenital Cytomegalovirus in Canada: Environmental Scan [Internet]","author":"Canadian Agency for Drugs and Technologies in Health","year":"2024"},{"key":"e_1_2_12_5_1","unstructured":"Centers for Disease Control and Prevention.2024.\u201cCongenital Cytomegalovirus (cCMV) Infection and Disease. 2024 Case Definition.\u201dAccessed November 24 2025.https:\/\/ndc.services.cdc.gov\/case\u2010definitions\/congenital\u2010cytomegalovirus\u2010ccmv\u2010infection\u2010and\u2010disease\u20102024\/."},{"key":"e_1_2_12_6_1","volume-title":"National Vital Statistics System, Natality, on CDC WONDER Online Database","author":"Centers for Disease Control and Prevention","year":"2025"},{"key":"e_1_2_12_7_1","unstructured":"Connecticut Chapter American Academy of Pediatrics.2025.\u201cConnecticut Expands Newborn Screening to Include Congenital Cytomegalovirus (cCMV). Effective July 1.\u201dhttps:\/\/ct\u2010aap.org\/connecticut\u2010expands\u2010newborn\u2010screening\u2010to\u2010include\u2010congenital\u2010cytomegalovirus\u2010ccmv\u2010effective\u2010july\u20101\u20102025\/."},{"key":"e_1_2_12_8_1","unstructured":"Council of State and Territorial Epidemiologists.2023.\u201cStandardized Surveillance Case Definition and National Notification for Congenital Cytomegalovirus (cCMV) Infection.\u201dhttps:\/\/cdn.ymaws.com\/www.cste.org\/resource\/resmgr\/ps\/ps_2023\/23\u2010ID\u201002_cCMV.pdf."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995\u2010010\u20100740\u20102"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.5441"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.544"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.007"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2024.5562"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016\u20102128"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.04.043"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014\u20101173"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1360"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7332a2"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.03.002"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00313\u201023"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHH.0000000000002043"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009\u20100913"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.30020"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.104231"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.01.016"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.20736"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004492"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.320"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.70025"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.70092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.70092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.70092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:42:34Z","timestamp":1786624954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.70092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/bdr2.70092"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.70092","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70092"}}