{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:18:52Z","timestamp":1787822332593,"version":"build-2784847793"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Dexketoprofen trometamol is a widely used short\u2010acting nonsteroidal anti\u2010inflammatory drug. Despite its widespread clinical use, pregnancy\u2010specific safety data for dexketoprofen as an individual agent are lacking, and no previous report has described maternal or fetal outcomes following overdose in pregnant women.<\/jats:p>\n <\/jats:sec>\n \n Cases<\/jats:title>\n We present three cases of intentional dexketoprofen overdose during pregnancy. Case 1 involved a 33\u2010year\u2010old woman at 8\u2009weeks of gestation who ingested dexketoprofen with ibuprofen, pseudoephedrine, and cefuroxime; she delivered a healthy male infant at 37\u2009weeks with no congenital anomalies on follow\u2010up. Case 2 involved a 36\u2010year\u2010old woman at 17\u2009weeks who ingested dexketoprofen with ergotamine tartrate, mecloxamine, caffeine, and paracetamol; she experienced a spontaneous abortion at 20\u2009weeks, complicated by cyst rupture requiring hysterectomy. Case 3 involved a 29\u2010year\u2010old woman at 6\u2009weeks who ingested dexketoprofen, paracetamol, and chlorpheniramine, and underwent elective termination at 10\u2009weeks.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The three cases demonstrated heterogeneous pregnancy outcomes. No congenital anomalies were identified in the single evaluable live\u2010born infant. Multiple co\u2010ingested agents substantially complicate causal attribution, most notably ergotamine tartrate in Case 2. The limited case number and outcome heterogeneity preclude identification of a consistent pattern of fetal adverse effects or definitive conclusions regarding fetal risk. All overdoses were intentional, underscoring the importance of integrating psychiatric assessment into toxicological management during pregnancy. These cases represent the first available observational data on maternal and fetal outcomes following intentional dexketoprofen overdose in pregnancy, highlighting the need for a multidisciplinary approach in this clinical setting.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/bdr2.70101","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:38:13Z","timestamp":1785379093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intentional Dexketoprofen Overdose During Pregnancy: Maternal and Fetal Outcomes in Three Cases"],"prefix":"10.1002","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-3951","authenticated-orcid":false,"given":"Nusret","family":"Uysal","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology Marmara University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesut","family":"Gungor","sequence":"additional","affiliation":[{"name":"TERAFAR (Izmir K\u00e2tip Celebi University Teratology Information, Training and Research Center) Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Karadas","sequence":"additional","affiliation":[{"name":"TERAFAR (Izmir K\u00e2tip Celebi University Teratology Information, Training and Research Center) Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"TERAFAR (Izmir K\u00e2tip Celebi University Teratology Information, Training and Research Center) Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Cem","family":"Kaplan","sequence":"additional","affiliation":[{"name":"TERAFAR (Izmir K\u00e2tip Celebi University Teratology Information, Training and Research Center) 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