{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:06:04Z","timestamp":1790255164133,"version":"4.1.0"},"reference-count":4,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["CDC\u2010RFA\u2010DD21\u20102101"],"award-info":[{"award-number":["CDC\u2010RFA\u2010DD21\u20102101"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Public health surveillance is critical for understanding disease burden, yet rigorous case confirmation often introduces significant latency. The Utah Birth Defect Network (\n                      <jats:styled-content style=\"fixed-case\">UBDN<\/jats:styled-content>\n                      ) utilizes a multistage active surveillance process that, while highly accurate, is a long and labor\u2010intensive process. This delay creates a barrier to timely family referrals for early intervention services. This study evaluates whether preliminary surveillance data is sufficiently accurate to initiate public health actions before final clinician confirmation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective analysis of 27 monitored birth defects for delivery years 2018\u20132025. Positive predictive values (\n                      <jats:styled-content style=\"fixed-case\">PPVs<\/jats:styled-content>\n                      ) were calculated for cases identified during initial medical record review by nonclinical staff compared with the \u201cgold standard\u201d of final clinician\u2010led confirmation. Analysis was performed using\n                      <jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content>\n                      version 9.4, with 95% confidence intervals calculated via the Wilson score method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1245 unique potential cases, the overall mean\n                      <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>\n                      was 68% (range: 8%\u201395%). Accuracy was highest for musculoskeletal defects (95%) and chromosomal anomalies (92%), with gastroschisis (95%), limb deficiencies (93%), and Trisomy 21 (92%) showing high stability. Cardiovascular defects demonstrated lower categorical accuracy (78%), with complex conditions like single ventricle (8%) showing the greatest diagnostic discordance. However, we observed categorical stability, as 77% of reclassified cardiovascular cases remained within the same body system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preliminary surveillance reviews demonstrate high diagnostic stability for the majority of monitored conditions. These findings validate the use of preliminary data to trigger early family\u2010centered referrals, significantly reducing the latency between case confirmation and intervention without compromising the integrity of formal reporting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.70119","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:48:51Z","timestamp":1789800531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accuracy of Preliminary Birth Defect Surveillance in Utah: A Validation Study Supporting Timely Family Referrals"],"prefix":"10.1002","volume":"118","author":[{"given":"Aubree","family":"Boyce","sequence":"first","affiliation":[{"name":"Utah Birth Defect Network, Utah Department of Health and Human Services  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4538-8821","authenticated-orcid":false,"given":"Stephanie","family":"Pocius","sequence":"additional","affiliation":[{"name":"Utah Birth Defect Network, Utah Department of Health and Human Services  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010publhealth\u2010031816\u2010044348"},{"key":"e_1_2_9_3_1","volume-title":"Guidelines for Conducting Birth Defects Surveillance","author":"National Birth Defects Prevention Network (NBDPN)","year":"2004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1843"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHH.0000000000000291"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.70119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.70119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.70119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:40:00Z","timestamp":1790253600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.70119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":4,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/bdr2.70119"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.70119","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70119"}}