{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:30:33Z","timestamp":1789979433673,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,7,24]],"date-time":"2003-07-24T00:00:00Z","timestamp":1059004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Like angiotensin converting enzyme (ACE) inhibitors angiotensin II (AT II)\u2010receptor\u2010antagonists may cause persistent or even lethal fetotoxic defects when used during the late second or third trimester. There are insufficient data on first\u2010trimester exposure to these substances in terms of teratogenicity. The two databases of the Berlin Teratology Information Service (TIS) were evaluated for pregnancy outcome following exposure to AT II\u2010receptor\u2010antagonists. One database covers case reports on newborns with congenital abnormalities identified after birth, in which drug\u2010effect associations can be evaluated retrospectively. The other enrolls women prospectively according to exposure to particular drugs during pregnancy, with follow\u2010up of pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASES<\/jats:title><jats:p>Five cases (four retrospective and one prospective) involving late\u2010pregnancy use of AT II\u2010receptor\u2010antagonists were recently reported to us, each of which included one or more of the following abnormalities: oligohydramnios\/anhydramnios, anuria, hypoplastic skull bones, limb contractions, lung hypoplasia, and neonatal death. Among 37 prospectively enrolled first\u2010trimester\u2010exposed pregnancies there were 30 live births including one with a major malformation (cleft palate). One pregnancy was electively terminated after exencephaly had been diagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>AT II\u2010receptor\u2010antagonists may induce fetotoxic effects when used in the second and third trimesters. The available data on first\u2010trimester use do not strongly support a teratogenic potential. AT II\u2010receptor\u2010antagonists should not be used by pregnant women. In case of inadvertent exposure, therapy should be changed to the known antihypertensives of choice (e.g., metoprolol, methyldopa, and hydralazine) and fetotoxic effects should be ruled out by ultrasound. Treatment with AT II\u2010receptor\u2010antagonists during early pregnancy is not in itself an indication for termination of a wanted pregnancy. Birth Defects Research (Part A), 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.10081","type":"journal-article","created":{"date-parts":[[2003,8,22]],"date-time":"2003-08-22T14:27:54Z","timestamp":1061562474000},"page":"591-594","source":"Crossref","is-referenced-by-count":106,"title":["Angiotensin II\u2010receptor\u2010antagonists: Further evidence of fetotoxicity but not teratogenicity"],"prefix":"10.1002","volume":"67","author":[{"given":"Christof","family":"Schaefer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420440503"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420500606"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04759-0"},{"key":"e_1_2_6_6_1","first-page":"133","article-title":"Persistent anuria in a neonate: a side effect of captopril?","volume":"2","author":"Guignard JP","year":"1981","journal-title":"Int J Pediatr Nephrol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04758-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1048"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009408"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04757-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05426-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03648-5"},{"key":"e_1_2_6_13_1","volume-title":"Drugs during pregnancy and lactation. Handbook of prescription drugs and comparative risk assessment","author":"Schaefer C","year":"2001"},{"key":"e_1_2_6_14_1","volume-title":"Arzneiverordnung in Schwangerschaft und Stillzeit","author":"Schaefer C","year":"2001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530380035028"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420510604"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.10081","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.10081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:26:15Z","timestamp":1696983975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.10081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,24]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1002\/bdra.10081"],"URL":"https:\/\/doi.org\/10.1002\/bdra.10081","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,24]]}}}