{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:51:00Z","timestamp":1775746260798,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T00:00:00Z","timestamp":1094515200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Neural tube defects (NTDs) occur as isolated malformations and in the company of other birth defects. This study was conducted to determine the frequency of coexisting anomalies and the relationship between them.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Since 1992, NTDs have been identified through prenatal and postnatal surveillance activities in South Carolina. The type of NTD and presence of associated anomalies were determined by prenatal ultrasound, postnatal and\/or postmortem examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>During the ten\u2010year period from 1992 to 2002, 564 NTDs were identified by the surveillance system. Seventeen percent of NTDs (98\/564) had associated malformations. In approximately half (n = 51) of these cases, the NTDs and associated anomalies were components of a recognizable syndrome. In the remaining cases (n = 47), no syndrome was identified or suspected, but the associated anomalies were believed in most instances to be secondary to space limitation or neural crest abnormalities imposed by the NTD.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Seventeen percent of NTDs in South Carolina have associated malformations. In most cases, the associated anomalies are considered either components of a multiple malformation syndrome or secondary to the NTD. Birth Defects Research (Part A) 70554\u2013558, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.20062","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T08:19:57Z","timestamp":1095149997000},"page":"554-558","source":"Crossref","is-referenced-by-count":43,"title":["Neural tube defects and associated anomalies in South Carolina"],"prefix":"10.1002","volume":"70","author":[{"given":"Roger E.","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie H.","family":"Seaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianne S.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane H.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199606)16:6<531::AID-PD914>3.0.CO;2-1"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Neural tube defect surveillance and folic acid intervention\u2014Texas\u2010Mexico border 1993\u20131998","volume":"49","author":"Centers for Disease Control and Prevention","year":"2000","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200205000-00006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320100105"},{"key":"e_1_2_6_6_1","first-page":"8781","article-title":"Food standards: amendment of the standards of identity for enriched grain products to require addition of folic acid","volume":"61","author":"US Department of Health and Human Services, Food and Drug Administration","year":"1996","journal-title":"Federal Register"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)91198-5"},{"key":"e_1_2_6_8_1","first-page":"827","article-title":"Clinical, genetic, and epidemiological factors in neural tube defects","volume":"43","author":"Hall JG","year":"1988","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_9_1","first-page":"662","article-title":"Congenital malformations in twins","volume":"22","author":"Hay S","year":"1970","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80759-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199611)54:5<213::AID-TERA1>3.0.CO;2-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014467600001661"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199802)57:2<56::AID-TERA3>3.0.CO;2-4"},{"key":"e_1_2_6_14_1","first-page":"980","article-title":"Etiologic heterogeneity of neural tube defects. II. Clues from family studies","volume":"34","author":"Khoury MJ","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)92487-8"},{"key":"e_1_2_6_16_1","volume-title":"Anencephaly","author":"Lemire RJ","year":"1978"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260406"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120408"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80278-4"},{"key":"e_1_2_6_20_1","unstructured":"SeaverLH StevensonRE DeanJ.2002.Neural tube defects with associated anomalies: recognized and unrecognized patterns of malformation. Paper presented at the 2ndbiennial Neural Tube Defects Conference Seabrook Island South Carolina May4\u20137 2002."},{"key":"e_1_2_6_21_1","volume-title":"Neural Tube Defects: From Origin to Treatment","author":"Seaver LH","year":"2003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250612"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.677"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210103"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0001566000008254"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.20062","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.20062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:31:19Z","timestamp":1695619879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.20062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1002\/bdra.20062"],"URL":"https:\/\/doi.org\/10.1002\/bdra.20062","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}