{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:30:57Z","timestamp":1786977057290,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The aim of this study was to detect possible etiological factors in the origin of isolated congenital cataracts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The data set of the Hungarian Case\u2010Control Surveillance of Congenital Abnormalities, 1980\u20132002, contains 111 cases of isolated congenital cataract and 111 matched control pairs without the defect, 37,837 population controls without any defects, and 22,744 malformed controls with other nonocular abnormalities. Exposure data and family history are based on prospective medical records, retrospective maternal information, and information obtained by regional nurses during a home visit with nonrespondent mothers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A positive family history indicated an autosomal\u2010dominant origin in 10% of cases. Rubella infections occurred more frequently in case mothers than in control mothers before vaccination against rubella virus was instituted. A higher prevalence of influenza or common cold during pregnancy was found in the case group (55.9%) than in the population control group (18.5%; adjusted odds ratios [ORs], 5.8; 95% confidence interval (CI), 4.0\u20138.4) or in the malformed control group (21.7%; adjusted OR, 4.7; 95% CI, 3.2\u20136.9). The prevalence of acute infectious diseases of the respiratory system during pregnancy was also higher in the case group (26.1%) than in the population control group (9.1%; adjusted OR, 3.8; 95% CI, 2.5\u20135.8), or the malformed control group (9.3%; adjusted OR, 3.4; 95% CI, 2.3\u20135.3). The higher risk for isolated congenital cataract in cases of mothers with influenza or common cold and acute infectious diseases of the respiratory system during pregnancy was not found after administration of antifever therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Some isolated congenital cataracts are preventable by rubella vaccination and probably by influenza vaccination in the epidemic period. In addition, our results suggest that using antifever therapy for fever\u2010related respiratory diseases may restrict the teratogenic risk of hyperthermia. Birth Defects Research (Part A), 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdra.20188","type":"journal-article","created":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T15:25:17Z","timestamp":1133450717000},"page":"997-1005","source":"Crossref","is-referenced-by-count":21,"title":["Population\u2010based case\u2010control study of isolated congenital cataract"],"prefix":"10.1002","volume":"73","author":[{"given":"G\u00e1bor","family":"Vogt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzs\u00e9bet","family":"Puh\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Czeizel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"22","volume-title":"Ophthalmology","author":"Azar NF","year":"2004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.4.341"},{"key":"e_1_2_5_4_1","first-page":"68","volume-title":"Genetics for ophthalmologists","author":"Black GCM","year":"2002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-831888"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200207000-00019"},{"key":"e_1_2_5_7_1","volume-title":"Multiple congenital abnormalities","author":"Czeizel AE","year":"1988"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199705)55:5<299::AID-TERA1>3.0.CO;2-V"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1999.tb00566.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1032"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.766"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770060610"},{"key":"e_1_2_5_13_1","first-page":"227","article-title":"Childhood blindness in the context of VISION 2020\u2014the right to sight","volume":"79","author":"Gilbert C","year":"2001","journal-title":"Bull World Health Org"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199811)58:5<209::AID-TERA8>3.0.CO;2-Q"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.041854jg"},{"key":"e_1_2_5_16_1","first-page":"2292","article-title":"A nationwide Danish study of 1027 cases of congenital\/infantile cataracts. 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