{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:06:28Z","timestamp":1761717988292},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T00:00:00Z","timestamp":1143676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>An increased risk for intrauterine growth restriction in the affected member of like\u2010sex twin pairs discordant for hypospadias has been reported. The purpose of this study was to document patterns of birth weight disparities in like\u2010sex twins discordant for a variety of structural defects in order to determine if this is a general phenomenon seen in twins who are discordant for any malformation, is seen only in pairs discordant for certain specific malformations, or is unique to hypospadias.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Data were extracted from the Latin American Collaborative Study of Congenital Malformations (ECLAMC). Between 1967 and 1999, all like\u2010sex twin pairs discordant for hypospadias or any other isolated defect that met the criteria of at least 5 discordant pairs for which birth weight was available on both twins were selected. All nonmalformed like\u2010sex twin pairs in the ECLAMC data base collected over the same study years were selected as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 216 discordant malformed like\u2010sex twin pairs in 13 defect categories and 328 nonmalformed like\u2010sex twin pairs met the criteria for inclusion. The proportion of affected infants who were \u226520% smaller than their co\u2010twin was statistically significantly different from controls for hypospadias, heart defects, anencephaly, and esophageal atresia.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Intrauterine growth restriction seen in the affected member of like\u2010sex twin pairs discordant for hypospadias is not unique, but occurs as well in at least 3 additional structural malformations. Birth Defects Research (Part A), 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.20247","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T20:16:27Z","timestamp":1143749787000},"page":"246-248","source":"Crossref","is-referenced-by-count":11,"title":["Intrauterine growth restriction in like\u2010sex twins discordant for structural defects"],"prefix":"10.1002","volume":"76","author":[{"given":"Christina D.","family":"Chambers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo E.","family":"Castilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ieda","family":"Orioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000104060.37475.29"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1375\/136905203322686536"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080776"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075064"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.50.10.791"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000023284"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62294-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(81)80343-0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1986.tb14935.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960122)61:3<216::AID-AJMG5>3.0.CO;2-S"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320100103"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(85)80021-X"},{"key":"e_1_2_5_14_1","first-page":"905","article-title":"Unsuspected organ abnormalities associated with congenital heart disease","volume":"47","author":"Naeye RL","year":"1965","journal-title":"Am J Pathol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.1.45"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.46.247.350"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61029-8"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1520029"},{"key":"e_1_2_5_19_1","unstructured":"ZonanaJ CheldelinLV NickelR.1986.Hypospadias and intrauterine growth retardation: a clinical association. 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