{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:06:32Z","timestamp":1790931992438,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T00:00:00Z","timestamp":1161129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND<\/jats:bold>: In the United States, birth defects affect approximately 3% of all births, are a leading cause of infant mortality, and contribute substantially to childhood morbidity. <jats:bold>METHODS<\/jats:bold>: Population\u2010based data from the National Birth Defects Prevention Network were combined to estimate the prevalence of 21 selected defects for 1999\u20132001, stratified by surveillance system type. National prevalence was estimated for each defect by pooling data from 11 states with active case\u2010finding, and adjusting for the racial\/ethnic distribution of US live births. We also assessed racial\/ethnic variation of the selected birth defects. <jats:bold>RESULTS<\/jats:bold>: National birth defect prevalence estimates ranged from 0.82 per 10,000 live births for truncus arteriosus to 13.65 per 10,000 live births for Down syndrome. Compared with infants of non\u2010Hispanic (NH) white mothers, infants of NH black mothers had a significantly higher birth prevalence of tetralogy of Fallot, lower limb reduction defects, and trisomy 18, and a significantly lower birth prevalence of cleft palate, cleft lip with or without cleft palate, esophageal atresia\/tracheoesophageal fistula, gastroschisis, and Down syndrome. Infants of Hispanic mothers, compared with infants of NH white mothers, had a significantly higher birth prevalence of anencephalus, spina bifida, encephalocele, gastroschisis, and Down syndrome, and a significantly lower birth prevalence of tetralogy of Fallot, hypoplastic left heart syndrome, cleft palate without cleft lip, and esophageal atresia\/tracheoesophageal fistula. <jats:bold>CONCLUSIONS<\/jats:bold>: This study can be used to evaluate individual state surveillance data, and to help plan for public health care and educational needs. It also provides valuable data on racial\/ethnic patterns of selected major birth defects. Birth Defects Research (Part A), 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20294","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T15:46:42Z","timestamp":1161186402000},"page":"747-756","source":"Crossref","is-referenced-by-count":534,"title":["National estimates and race\/ethnic\u2010specific variation of selected birth defects in the United States, 1999\u20132001"],"prefix":"10.1002","volume":"76","author":[{"given":"Mark A.","family":"Canfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret 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