{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:08:54Z","timestamp":1791230934430,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,25]],"date-time":"2006-09-25T00:00:00Z","timestamp":1159142400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> The fortification of wheat flour with folic acid prevents most cases of spina bifida and anencephaly by raising serum folate levels among women capable of bearing children, as does encouraging women to consume folic acid supplements prior to pregnancy. Unfortunately, surveillance is conducted in few countries where the need is greatest. <jats:bold>METHODS:<\/jats:bold> A method for assessing the prevention of these birth defects is presented that combines fortification program information with country case prevalence estimates. <jats:bold>RESULTS:<\/jats:bold> This approach suggests that about 70% of all cases could be prevented within a year of implementation of fortification programs, were it not for the inertia of regulatory agencies. <jats:bold>CONCLUSIONS:<\/jats:bold> Professional researchers and clinicians can help combat this situation by becoming advocates for child health in their respective countries. Birth Defects Research (Part A) 76:654\u2013657, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20304","type":"journal-article","created":{"date-parts":[[2006,9,25]],"date-time":"2006-09-25T23:30:31Z","timestamp":1159227031000},"page":"654-657","source":"Crossref","is-referenced-by-count":32,"title":["Tracking the prevention of folic acid\u2013preventable spina bifida and anencephaly"],"prefix":"10.1002","volume":"76","author":[{"given":"Karen N.","family":"Bell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Godfrey P.","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,25]]},"reference":[{"issue":"14","key":"e_1_2_3_2_1","first-page":"1","article-title":"Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects","volume":"41","author":"CDC","year":"1992","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_3_3_1","volume-title":"March of Dimes global report on birth defects: the hidden toll of dying and disabled children","author":"Christianson A","year":"2006"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"e_1_2_3_5_1","first-page":"8781","article-title":"U.S. Food and Drug Administration. Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid","volume":"61","author":"FDA","year":"1996","journal-title":"Fed Regist"},{"key":"e_1_2_3_6_1","first-page":"564","volume-title":"Dietary reference intakes for thiamin, riboflavin, niacin, folate, vitamin B12, pantothenic acid, biotin, and choline","author":"Food and Nutrition Board","year":"1998"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20058"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07104-5"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.20304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.20304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T13:07:14Z","timestamp":1694610434000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.20304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1002\/bdra.20304"],"URL":"https:\/\/doi.org\/10.1002\/bdra.20304","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}