{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:54:08Z","timestamp":1771610048002,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T00:00:00Z","timestamp":1199664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> Previously the first trimester, later the 2nd and\/or 3rd gestational months were evaluated at the analysis of different exposures in different congenital abnormalities. However, different congenital abnormalities have different critical periods. The objective of this study was to check the feasibility of a new approach to consider the specified critical periods of different congenital abnormalities separately. <jats:bold>METHODS:<\/jats:bold> The potential teratogenic effect of oral ampicillin treatment and maternal influenza\/fever during the study pregnancy regarding any time in pregnancy, during the first trimester, in the 2nd and\/or 3rd gestational months, and finally in the specified critical periods of given congenital abnormalities were evaluated in the population\u2010based large data set of the Hungarian Case\u2010Control Surveillance System of Congenital Abnormalities. <jats:bold>RESULTS:<\/jats:bold> Of 22,843 cases, 1644 (7.2%) and 1328 (5.8%) were born to mothers who had oral ampicillin treatment or were affected with influenza\/fever during the study pregnancy, while of 38,151 control newborns without any defect, 2631 (6.9 %) and 1838 (4.8%) had mothers with ampicillin treatment or influenza\/fever, respectively. The analysis of different exposure time windows showed some difference in the risk for congenital abnormalities. The use of specified critical periods of different congenital abnormalities was feasible. <jats:bold>CONCLUSIONS:<\/jats:bold> The use of specified critical periods of different congenital abnormalities seems to be more scientific\u2010based than the previously accepted methods for the evaluation of different exposure time windows. Thus this new and feasible approach is recommended for the controlled epidemiological studies in the future after an international consensus in the specified critical periods of different congenital abnormalities and other methodological issues. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20431","type":"journal-article","created":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T00:16:43Z","timestamp":1199751403000},"page":"139-146","source":"Crossref","is-referenced-by-count":38,"title":["Use of specified critical periods of different congenital abnormalities instead of the first trimester concept"],"prefix":"10.1002","volume":"82","author":[{"given":"Andrew E.","family":"Czeizel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet H.","family":"Puh\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"B\u00e1nhidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,7]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"589","article-title":"Maternal influenza during pregnancy and risk of congenital abnormalities in offspring","volume":"73","author":"\u00c1cs N","year":"2005","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.2.100"},{"key":"e_1_2_5_4_1","volume-title":"Drugs in pregnancy and lactation","author":"Briggs GG","year":"2005"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199705)55:5<299::AID-TERA1>3.0.CO;2-V"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2001.tb00834.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6876.499"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1032"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.113907"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.766"},{"key":"e_1_2_5_11_1","first-page":"55","volume-title":"Birth defects: new research","author":"Czeizel AE","year":"2006"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(87)90058-3"},{"key":"e_1_2_5_13_1","volume-title":"Smiths recognizable patterns of human malformations","author":"Jones KL","year":"2006"},{"key":"e_1_2_5_14_1","first-page":"223","volume-title":"Methods of teratological studies in experimental animals and man","author":"Nishimura H","year":"1969"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200107000-00017"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(92)90040-G"},{"key":"e_1_2_5_17_1","volume-title":"Catalog of teratogenic agents","author":"Shepard TH","year":"2004"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.20431","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.20431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:06:03Z","timestamp":1697432763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.20431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,7]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/bdra.20431"],"URL":"https:\/\/doi.org\/10.1002\/bdra.20431","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,7]]}}}