{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:35:12Z","timestamp":1789724112643,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T00:00:00Z","timestamp":1205280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> Our objective was to estimate the mortality rate in subjects with fetal alcohol spectrum disorders (FASD) and their siblings whose FASD status was unknown. <jats:bold>METHODS:<\/jats:bold> We used the state FASD Registry to link subjects with FASD to a North Dakota birth certificate. We were able to link 304 of 486 cases (63%). We used the birth certificates to identify the mother and children born to the mother (siblings). We then searched for death certificates for both the FASD cases and their siblings. We then calculated the annual and age\u2010adjusted mortality rates for the siblings of the Registry cases and compared them with mortality rates from North Dakota. <jats:bold>RESULTS:<\/jats:bold> The FASD case mortality rate was 2.4%, with a 4.5% mortality rate for their sibings, accounting for 14% of all deaths when compared to the North Dakota residents matched by age and year of death. The sibling deaths accounted for 21.5% of all cause mortality matched by age and year of death. The age\u2010standardized mortality ratios were 4.9 for the FASD cases and 2.6 for their siblings whose FASD status was unknown. <jats:bold>CONCLUSIONS:<\/jats:bold> Mortality rates for FASD cases and their siblings were increased and represent a substantial proportion of all cause mortality in North Dakota. Prevention of FASD may be a useful strategy to decrease mortality. Birth Defects Research (Part A), 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20445","type":"journal-article","created":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T21:51:37Z","timestamp":1205358697000},"page":"217-223","source":"Crossref","is-referenced-by-count":46,"title":["Mortality rates in subjects with fetal alcohol spectrum disorders and their siblings"],"prefix":"10.1002","volume":"82","author":[{"given":"Larry","family":"Burd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn G.","family":"Klug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Bueling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Martsolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Kerbeshian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-5217-5"},{"key":"e_1_2_6_3_1","volume-title":"Diagnostic guide for fetal alcohol syndrome and related conditions: The 4\u2010digit diagnostic code","author":"Astley SJ","year":"1999"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556210410001717088"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2003.07.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30016"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF03403884","article-title":"Mortality in fetal alcohol syndrome","volume":"88","author":"Habbick BF","year":"1997","journal-title":"Can J Public Health"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0259"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.21.2717"},{"key":"e_1_2_6_11_1","volume-title":"Epidemiology, biostatistics, and preventive medicine","author":"Jekel JF","year":"1996"},{"key":"e_1_2_6_12_1","first-page":"476","article-title":"Les enfants de parents alcooliques: Anomalies observee a propos de 127 cas [The children of alcoholic parents: Anomalies observed in 127 cases]","volume":"21","author":"Lemoine P","year":"1968","journal-title":"Quest Medicale"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199711)56:5<317::AID-TERA5>3.0.CO;2-U"},{"key":"e_1_2_6_14_1","volume-title":"Fetal alcohol syndrome\u2010diagnosis, epidemiology, prevention, and treatment","author":"Stratton KR","year":"1996"},{"key":"e_1_2_6_15_1","volume-title":"Understanding the occurrence of secondary disabilities in clients with FAS and FAE. 96\u20130. 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