{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:18:13Z","timestamp":1768889893267,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T00:00:00Z","timestamp":1211328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> Asplenia or polysplenia and complex cardiovascular defects, in association with disturbed body symmetry and malposition of internal organs, constitute the main corpus of malformations in the heterogeneous group of heterotaxy disorders. In affected pregnancies, prenatal diagnosis is possible by ultrasonography, while prognosis and counseling largely depend upon the severity of the cardiac defect. <jats:bold>CASE:<\/jats:bold> We present a 25 week gestation fetus with typical findings of asplenia\u2013cardiovascular defect\u2013heterotaxy (Ivemark syndrome) and aplasia of the pancreas. <jats:bold>CONCLUSIONS:<\/jats:bold> Pancreatic aplasia emerges as an additional phenotypic feature in Ivemark syndrome and raises the possibility of total pancreatic insufficiency of the affected neonate as an additional, although rare, clinical consideration. Birth Defects Research (Part A) 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20467","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T18:37:52Z","timestamp":1211395072000},"page":"601-604","source":"Crossref","is-referenced-by-count":8,"title":["Pancreatic aplasia in a fetus with asplenia\u2010cardiovascular defect\u2010heterotaxy (Ivemark syndrome)"],"prefix":"10.1002","volume":"82","author":[{"given":"Anastasia","family":"Konstantinidou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavros","family":"Sifakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ourania","family":"Koukoura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikitas","family":"Mantas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Agrogiannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstratios","family":"Patsouris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-6806"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.381906"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1219"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000131)90:3<185::AID-AJMG1>3.0.CO;2-Y"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31972"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087625"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.05.039"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1066503"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2007.01.009"},{"key":"e_1_2_4_11_1","first-page":"345","article-title":"Abnormal 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