{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:01:33Z","timestamp":1759564893974},"reference-count":6,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,23]],"date-time":"2009-02-23T00:00:00Z","timestamp":1235347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> The possible association between maternal appendicitis\/appendectomy during pregnancy and congenital abnormalities in the offspring was studied. <jats:bold>CASES:<\/jats:bold> Two cases with primary microcephaly were born to mothers who had complicated appendicitis owing to the delay of appendectomy resulting in abscess\/peritonitis associated with septicemia and fever in the second trimester of pregnancy. <jats:bold>CONCLUSIONS:<\/jats:bold> Delay in surgical intervention of appendicitis in pregnancy can result in maternal morbidity that may be associated with primary microcephaly in the offspring. Birth Defects Research (Part A), 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20569","type":"journal-article","created":{"date-parts":[[2009,2,23]],"date-time":"2009-02-23T19:41:49Z","timestamp":1235418109000},"page":"655-656","source":"Crossref","is-referenced-by-count":3,"title":["Primary microcephaly in two children born to mothers with complicated appendicitis or late appendectomy during pregnancy"],"prefix":"10.1002","volume":"85","author":[{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"B\u00e1nhidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E.","family":"Czeizel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1908.25410160020001f"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004040050221"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1032"},{"key":"e_1_2_4_5_1","first-page":"835","article-title":"Appendectomy during pregnancy: a Swedish registry study of 778 cases","volume":"77","author":"Mazze RI","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.05.025"},{"key":"e_1_2_4_7_1","first-page":"223","volume-title":"Method of teratological studies in experimental animals and man","author":"Nishimura H","year":"1969"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.20569","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.20569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T19:48:51Z","timestamp":1699904931000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.20569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,23]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1002\/bdra.20569"],"URL":"https:\/\/doi.org\/10.1002\/bdra.20569","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,23]]}}}