{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:17:37Z","timestamp":1767651457023},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T00:00:00Z","timestamp":1255478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Cost estimates for birth defects are useful to policy makers in deciding the best use of resources to prevent these conditions. Much of the effort in this area has focused on spina bifida, in part because cost savings can be estimated from folic acid\u2013preventable cases. However, comprehensive cost\u2010of\u2010illness estimates for this condition may be too outdated, too general, or not applicable to individual states' environments.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Using the live birth prevalence for spina bifida in Texas, we applied recent spina bifida cost estimates to approximate total lifetime medical and other costs for an average live birth cohort of spina bifida cases in Texas. In addition, we queried various government programs that provide services for persons with spina bifida to provide program\u2010specific annual costs for this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Applying a recently published average lifetime medical cost of $635,000 per case of spina bifida to the average annual birth cohort of 120 Texas cases, an estimated $76 million in direct and indirect medical and other costs will be incurred in Texas over the life span of that cohort. Examples of estimated medical costs for one year are $5 million for infants using actual employer\u2010paid insurance claims data and $6 million combined for children in two public sector programs.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION:<\/jats:title><jats:p>Stakeholders and state policy makers may look to state birth defects registries for useful cost data. Although comprehensive state\u2010specific figures are not available, applying prevalence data to existing estimates and obtaining actual claims and program expenditures may help close this information gap. Birth Defects Research (Part A) 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.20637","type":"journal-article","created":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T00:26:24Z","timestamp":1255566384000},"page":"920-924","source":"Crossref","is-referenced-by-count":5,"title":["Methods for developing useful estimates of the costs associated with birth defects"],"prefix":"10.1002","volume":"85","author":[{"given":"Amy P.","family":"Case","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Canfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Agency for Healthcare Research and Quality.2008. Healthcare Cost and Utilization Project (HCUP). Available at:http:\/\/hcupnet.ahrq.gov\/HCUPnet.jsp. Accessed December 7 2008."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3549(04)50275-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1364"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20294"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2008.07.008"},{"key":"e_1_2_6_7_1","unstructured":"Kaiser Family Foundation.2008. State health facts. Available at:http:\/\/www.statehealthfacts.kff.org\/. Accessed December 7 2008."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.4.906"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20360"},{"key":"e_1_2_6_10_1","volume-title":"State special education finance systems, 1999\u20132000: Part I","author":"Parrish T","year":"2003"},{"key":"e_1_2_6_11_1","first-page":"5","article-title":"Use of supplements containing folic acid among women of childbearing age\u2014United States, 2007","volume":"57","author":"Petrini JR","year":"2008","journal-title":"MMWR: Morbidity & Mortality Weekly Report"},{"key":"e_1_2_6_12_1","first-page":"334","article-title":"The TEFRA Medicaid eligibility option for children with severe disabilities: a national study","volume":"31","author":"Semansky R","year":"2004","journal-title":"J Behav Health Serv Res"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3308"},{"key":"e_1_2_6_14_1","volume-title":"Texas birth defects monitor 12:2","author":"Texas Department of State Health Services","year":"2006"},{"key":"e_1_2_6_15_1","volume-title":"Texas birth defects registry report of birth defects among 1999\u20132004 deliveries","author":"Texas Department of State Health Services","year":"2007"},{"key":"e_1_2_6_16_1","unstructured":"Texas Department of State Health Services.2008. Pregnancy outcome distribution for selected birth defects Texas birth defects registry report of birth defects among 1999\u20132005 deliveries Available at:www.dshs.state.tx.us\/birthdefects\/data\/reports.shtm. Accessed December 10 2008."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X08322014"},{"key":"e_1_2_6_18_1","volume-title":"The half\u2010life of cost\u2010of\u2010illness estimates: the case of spina bifida. Working Paper Series, Department of Economics, University of Utah 2004_07","author":"Waitzman N","year":"2004"},{"key":"e_1_2_6_19_1","volume-title":"The cost of birth defects: estimates of the value of prevention","author":"Waitzman N","year":"1996"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.20637","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.20637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T10:14:51Z","timestamp":1694513691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.20637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,14]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/bdra.20637"],"URL":"https:\/\/doi.org\/10.1002\/bdra.20637","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,14]]}}}