{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:30:58Z","timestamp":1775655058225,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T00:00:00Z","timestamp":1274918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Many studies from the Western world have indicated that maternal obesity is associated with an increased risk of neural tube defects (NTDs). However, few reports have been available on this association from Asian populations. Our aim was to examine the relationship between maternal prepregnancy body mass index (BMI) and the risk of NTDs in a population of northern China.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Data were derived from an ongoing population\u2010based case\u2013control study of birth defects in Shanxi province, China. Subjects were 511 NTD cases and 687 controls selected from the same population between January 2003 and June 2007. BMI was based on maternal height and prepregnancy weight as reported within 1 week of delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>We found no significantly increased risk of NTDs for obese women (adjusted odds ratio [OR], 0.65; 95% confidence interval [CI], 0.29\u20131.49) or for underweight women (adjusted OR, 1.00; 95% CI, 0.62\u20131.62) relative to normal\u2010weight women. We found a significantly reduced risk of overall NTDs (adjusted OR, 0.56; 95% CI, 0.41\u20130.76) and anencephaly (adjusted OR, 0.40; 95% CI, 0.26\u20130.62) for overweight women compared to normal\u2010weight women.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Our results do not support the association between maternal prepregnancy obesity and increased risk of overall NTDs or of any subtype of NTDs in the Chinese population. Birth Defects Research (Part A) 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.20678","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T14:30:09Z","timestamp":1274970609000},"page":"570-574","source":"Crossref","is-referenced-by-count":8,"title":["Maternal prepregnancy body mass index and risk of neural tube defects: A population\u2010based case\u2013control study in Shanxi province, China"],"prefix":"10.1002","volume":"88","author":[{"given":"Zhiwen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongwei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiguo","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000147122.97061.bb"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20620"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420420412"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-9523(03)00281-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020916"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1982.tb04646.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200111000-00009"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90655-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009408"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043659606288377"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01045.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20248"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2006.00694.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20342"},{"key":"e_1_2_5_16_1","first-page":"252","article-title":"Prevalence of major external birth defects in high and low risk areas in China, 2003","volume":"26","author":"Li ZW","year":"2005","journal-title":"Chin J Epidemiol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200011000-00013"},{"key":"e_1_2_5_18_1","volume-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults","author":"National Institutes of Health","year":"1998"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.021"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg043"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000151988.84346.3e"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980007246786"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181761fa3"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530380035028"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199911000-00022"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010059"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1981.tb01759.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70224-1"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.161.8.745"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.S1.1152"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199609000-00010"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530380031027"},{"key":"e_1_2_5_33_1","volume-title":"Obesity: preventing and managing the global epidemic. 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