{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:16:18Z","timestamp":1760217378189},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T00:00:00Z","timestamp":1281571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To understand the complex etiology of developmental disorders, an understanding of both genetic and environmental risk factors is needed. Human and rodent genetic studies have identified a multitude of gene candidates for specific developmental disorders such as neural tube defects (NTDs). With the emergence of toxicogenomic\u2010based assessments, scientists now also have the ability to compare and understand the expression of thousands of genes simultaneously across strain, time, and exposure in developmental models. Using a systems\u2010based approach in which we are able to evaluate information from various parts and levels of the developing organism, we propose a framework for integrating genetic information with toxicogenomic\u2010based studies to better understand gene\u2010environmental interactions critical for developmental disorders. This approach has allowed us to characterize candidate genes in the context of variables critical for determining susceptibility such as strain, time, and exposure. Using a combination of toxicogenomic studies and complementary bioinformatic tools, we characterize NTD candidate genes during normal development by function (gene ontology), linked phenotype (disease outcome), location, and expression (temporally and strain\u2010dependent). In addition, we show how environmental exposures (cadmium, methylmercury) can influence expression of these genes in a strain\u2010dependent manner. Using NTDs as an example of developmental disorder, we show how simple integration of genetic information from previous studies into the standard microarray design can enhance analysis of gene\u2010environment interactions to better define environmental exposure\u2010disease pathways in sensitive and resistant mouse strains. Birth Defects Research (Part A), 2010. \u00a9 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20708","type":"journal-article","created":{"date-parts":[[2010,8,13]],"date-time":"2010-08-13T00:21:52Z","timestamp":1281658912000},"page":"920-930","source":"Crossref","is-referenced-by-count":8,"title":["Integrating genetic and toxicogenomic information for determining underlying susceptibility to developmental disorders"],"prefix":"10.1002","volume":"88","author":[{"given":"Joshua F.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse A.","family":"Port","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine 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