{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:55:30Z","timestamp":1779080130127,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T00:00:00Z","timestamp":1284422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND:<\/jats:bold> The application of magnetic resonance microscopy (MRM) to the study of normal and abnormal prenatal mouse development has facilitated discovery of dysmorphology following prenatal ethanol insult. The current analyses extend this work, providing a regional brain volume\u2010based description of normal braingrowth and illustrating the consequences of gestational day (GD) 10 ethanol exposure in the fetal mouse. <jats:bold>METHODS:<\/jats:bold> To assess normal growth, control C57Bl\/6J fetuses collected on GD 16, GD 16.5, and GD 17 were scanned using a 9.4\u2010T magnet, resulting in 29\u2010\u03bcm isotropic resolution images. For the ethanol teratogenicity studies, C57Bl\/6J dams were administered intraperitoneal ethanol (2.9 g\/kg) at 10 days, 0 hr, and 10 days, 4 hr, after fertilization, and fetuses were collected for analyses on GD 17. From individual MRM scans, linear measurements and regional brain volumes were determined and compared. <jats:bold>RESULTS:<\/jats:bold> In control fetuses, each of the assessed brain regions increased in volume, whereas ventricular volumes decreased between GD 16 and GD 17. Illustrating a global developmental delay, prenatal ethanol exposure resulted in reduced body volumes, crown\u2010rump lengths, and a generalized decrease in regional brain volumes compared with GD 17 controls. However, compared with GD 16.5, morphologically matched controls, ethanol exposure resulted in volume increases in the lateral and third ventricles as well as a disproportionate reduction in cortical volume. <jats:bold>CONCLUSIONS:<\/jats:bold> The normative data collected in this study facilitate the distinction between GD 10 ethanol\u2010induced developmental delay and frank dysmorphology. This work illustrates the utility of MRM\u2010based analyses for developmental toxicology studies and extends our knowledge of the stage\u2010dependency of ethanol teratogenesis. Birth Defects Research (Part A), 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20719","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T12:53:37Z","timestamp":1284468817000},"page":"953-964","source":"Crossref","is-referenced-by-count":55,"title":["Magnetic resonance microscopy\u2010based analyses of the brains of normal and ethanol\u2010exposed fetal mice"],"prefix":"10.1002","volume":"88","author":[{"given":"Shonagh K.","family":"O'Leary\u2010Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott E.","family":"Parnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Godin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah B.","family":"Dehart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob J.","family":"Ament","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Allan","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin A.","family":"Styner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen K.","family":"Sulik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01184.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02274.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02129.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","unstructured":"BurkeMW PalmourRM ErvinFR et al.2009.Neuronal reduction in frontal cortex of primates after prenatal alcohol exposure. Neuroreport20:13\u201317.","DOI":"10.1097\/WNR.0b013e32831b449c"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1001\/jama.1981.03310480052033","article-title":"Recognition of fetal alcohol syndrome","volume":"245","author":"Clarren SK.","year":"1981","journal-title":"JAMA"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80072-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540070083022"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02156.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2195"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01071.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1767"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.05.013"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960202)61:4<329::AID-AJMG6>3.0.CO;2-P"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91092-1"},{"key":"e_1_2_5_16_1","volume-title":"The atlas of mouse development","author":"Kaufman MH.","year":"1992"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6379"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s004010000257","article-title":"Prenatal exposure to ethanol induces leptomeningeal heterotopia in the cerebral cortex of the rat fetus","volume":"101","author":"Komatsu S","year":"2001","journal-title":"Acta Neuropathol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500329775"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-009-0474-7"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(94)90050-7"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.68"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(01)00168-4"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902930108"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.72"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.08.001"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.00921.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(79)90033-9"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20932"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-345-9_11"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805747105"},{"key":"e_1_2_5_32_1","unstructured":"RasbandWS.1997\u20132009. ImageJ U.S. National Institutes of Health Bethesda Maryland USA http:\/\/rsb.info.nih.gov\/ij\/"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20629"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0901-8"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-47093-1"},{"key":"e_1_2_5_36_1","volume-title":"Atlas of prenatal mouse brain","author":"Schambra UB","year":"1992"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20010201)52:3<323::AID-JEMT1016>3.0.CO;2-F"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.22.2996"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm039"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200103050-00018"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1328"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.09.006"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(84)90014-5"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn334"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.2.232"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88418-4"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1146"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.01.005"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01669.x"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.015"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(03)00158-5"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.20719","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.20719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T15:20:28Z","timestamp":1697469628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.20719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,14]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1002\/bdra.20719"],"URL":"https:\/\/doi.org\/10.1002\/bdra.20719","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,14]]}}}