{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:18:55Z","timestamp":1792462735518,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T00:00:00Z","timestamp":1299196800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>As part of EUROCAT's surveillance of congenital anomalies in Europe, a statistical monitoring system has been developed to detect recent clusters or long\u2010term (10 year) time trends. The purpose of this article is to describe the system for the identification and investigation of 10\u2010year time trends, conceived as a \u201cscreening\u201d tool ultimately leading to the identification of trends which may be due to changing teratogenic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The EUROCAT database consists of all cases of congenital anomalies including livebirths, fetal deaths from 20 weeks gestational age, and terminations of pregnancy for fetal anomaly. Monitoring of 10\u2010year trends is performed for each registry for each of 96 non\u2010independent EUROCAT congenital anomaly subgroups, while Pan\u2010Europe analysis combines data from all registries. The monitoring results are reviewed, prioritized according to a prioritization strategy, and communicated to registries for investigation. Twenty\u2010one registries covering over 4 million births, from 1999 to 2008, were included in monitoring in 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Significant increasing trends were detected for abdominal wall anomalies, gastroschisis, hypospadias, Trisomy 18 and renal dysplasia in the Pan\u2010Europe analysis while 68 increasing trends were identified in individual registries. A decreasing trend was detected in over one\u2010third of anomaly subgroups in the Pan\u2010Europe analysis, and 16.9% of individual registry tests. Registry preliminary investigations indicated that many trends are due to changes in data quality, ascertainment, screening, or diagnostic methods. Some trends are inevitably chance phenomena related to multiple testing, while others seem to represent real and continuing change needing further investigation and response by regional\/national public health authorities. Birth Defects Research (Part A), 2011.\u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.20778","type":"journal-article","created":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T19:57:27Z","timestamp":1299268647000},"source":"Crossref","is-referenced-by-count":142,"title":["Paper 4: EUROCAT statistical monitoring: Identification and investigation of ten year trends of congenital anomalies in Europe"],"prefix":"10.1002","volume":"91","author":[{"given":"Maria","family":"Loane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Dolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Teljeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Greenlees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Densem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and a EUROCAT Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471249688"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181c2979b"},{"key":"e_1_2_6_4_1","unstructured":"EUROCAT.2004. EUROCAT special report: a review of environmental risk factors for congenital anomaly 2004. Accessed 27th January 2011.http:\/\/www.eurocat\u2010network.eu\/content\/Special\u2010Report\u2010Env\u2010Risk\u2010I\u2010and\u2010II.pdfandhttp:\/\/www.eurocat\u2010network.eu\/content\/Special\u2010Report\u2010Env\u2010Risk\u2010III.pdf). Accessed 27th January 2011."},{"key":"e_1_2_6_5_1","unstructured":"EUROCAT.2005. EUROCAT guide 1.3. Instructions for the registration and surveillance of congenital anomalieshttp:\/\/www.eurocat\u2010network. eu\/ABOUTUS\/DataCollection\/GuidelinesforRegistration\/Guide1_ 3InstructionManual. Accessed 27th January 2011"},{"key":"e_1_2_6_6_1","unstructured":"EUROCAT.2009a.Special report: prevention of neural tube defects by periconceptional folic acid supplementation in Europe. EUROCAT Central Registry University of Ulster Belfast UK."},{"key":"e_1_2_6_7_1","unstructured":"EUROCAT.2009b.Special report: congenital heart defects in Europe 2000\u20132005. EUROCAT Central Registry University of Ulster Belfast UK."},{"key":"e_1_2_6_8_1","unstructured":"EUROCAT.2010a. EUROCAT Statistical Monitoring Protocol 2008http:\/\/www.eurocat\u2010network.eu\/content\/EUROCAT\u2010Statistical\u2010Monitoring\u2010Protocol\u20102008.pdf.Accessed 27th January 2011."},{"key":"e_1_2_6_9_1","unstructured":"EUROCAT.2010b. EUROCAT Statistical Monitoring Report 2007.http:\/\/www.eurocat\u2010network.eu\/content\/Stat\u2010Mon\u2010Report\u20102007.pdf. Accessed 27th January 2011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2007.00820.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31819f3bc0"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.20778","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.20778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T22:46:10Z","timestamp":1694645170000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.20778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":10,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/bdra.20778"],"URL":"https:\/\/doi.org\/10.1002\/bdra.20778","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}