{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:54:01Z","timestamp":1791219241703,"version":"4.1.0"},"reference-count":128,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T00:00:00Z","timestamp":1307318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epigenetics, and in particular imprinted genes, have a critical role in the development and function of the placenta, which in turn has a central role in the regulation of fetal growth and development. A unique characteristic of imprinted genes is their expression from only one allele, maternal or paternal and dependent on parent of origin. This unique expression pattern may have arisen as a mechanism to control the flow of nutrients from the mother to the fetus, with maternally expressed imprinted genes reducing the flow of resources and paternally expressed genes increasing resources to the fetus. As a result, any epigenetic deregulation affecting this balance can result in fetal growth abnormalities. Imprinting\u2010associated disorders in humans, such as Beckwith\u2010Wiedemann and Angelman syndrome, support the role of imprinted genes in fetal growth. Similarly, assisted reproductive technologies in animals have been shown to affect the epigenome of the early embryo and the expression of imprinted genes. Their role in disorders such as intrauterine growth restriction appears to be more complex, in that imprinted gene expression can be seen as both causative and protective of fetal growth restriction. This protective or compensatory effect needs to be explored more fully. \u00a9 Birth Defects Research (Part A), 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20795","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T19:17:03Z","timestamp":1307387823000},"page":"682-692","source":"Crossref","is-referenced-by-count":105,"title":["The role of imprinted genes in fetal growth abnormalities"],"prefix":"10.1002","volume":"91","author":[{"given":"Jorge 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