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Once their fates are specified, neural crest cells (NCCs) migrate along defined routes and differentiate into a variety of tissues, including bone and cartilage of the craniofacial skeleton, peripheral neurons, glia, pigment cells, endocrine cells, and mesenchymal precursor cells (Santagati and Rijli,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib96\">2003<\/jats:ext-link>; Dupin et al.,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib33\">2006<\/jats:ext-link>; Hall,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib48\">2009<\/jats:ext-link>). Abnormal development of NCCs causes a number of human diseases, including ear abnormalities (including deafness), heart anomalies, neuroblastomas, and mandibulofacial dysostosis (Hall,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib48\">2009<\/jats:ext-link>). For more than a century, NCCs have attracted the attention of geneticists and developmental biologists for their stem cell\u2010like properties, including self\u2010renewal and multipotent differentiation potential. However, we have only begun to understand the underlying mechanisms responsible for their formation and behavior. Recent studies have demonstrated that epigenetic regulation plays important roles in NC development. In this review, we focused on some of the most recent findings on chromatin\u2010mediated mechanisms for vertebrate NCC development. Birth Defects Research (Part A), 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.20797","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T13:14:33Z","timestamp":1306329273000},"page":"788-796","source":"Crossref","is-referenced-by-count":19,"title":["Epigenetic regulation in neural crest 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