{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:56:08Z","timestamp":1780354568700,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:00:00Z","timestamp":1317168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neural tube defects (NTDs), most commonly spina bifida and anencephaly, can be prevented with periconceptional intake of folic acid in about 70% of cases. Recurrence of NTDs despite supplementation of high dose of folic acid further suggests that a proportion of NTD cases might be resistant to folic acid. Moreover, heterogeneity of NTDs has been suggested in animal studies, indicating that only some sub\u2010type of NTDs should be considered sensitive to folate intake. Inositol isomers (particularly myo\u2010 and chiro\u2010inositol) can prevent folate\u2010resistant NTDs in the curly\u2010tail mutant mouse, suggesting that some cases of human NTDs might benefit from inositol supplementation. In humans, lower inositol blood concentration was found in pregnant women carrying NTD fetuses, whereas a periconceptional combination therapy with folic acid associated with inositol has been linked to normal live births, despite high NTD recurrence risk. Fifteen pregnancies from 12 Caucasian women from different parts of Italy with at least one previous NTD\u2010affected pregnancy underwent periconceptional combined myo\u2010inositol and folic acid supplementation. Maternal serum \u03b1\u2010feto\u2010protein levels were found in the normal range, and normal results on ultrasound examination were found in all the pregnancies that followed. No collateral effects or intense uterine contractions were demonstrated in this pilot study in any of the pregnancies after inositol supplementation, and seventeen babies were born without any type of NTD. Birth Defects Research (Part A), 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/bdra.22853","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T20:32:57Z","timestamp":1317241977000},"page":"962-965","source":"Crossref","is-referenced-by-count":44,"title":["Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy"],"prefix":"10.1002","volume":"91","author":[{"given":"Pietro","family":"Cavalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Tonni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Grosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Poggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.7.1084"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1986"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.2.e5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20454"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh003"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.9.2451"},{"key":"e_1_2_5_9_1","first-page":"432","article-title":"Inositol\u2013clinical applications for exogenous use","volume":"3","author":"Colodny L","year":"1998","journal-title":"Altern Med Rev"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211349"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0197-60"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00807-X"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508149200"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000366"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38036.646030.EE"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01273191"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904293401703"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200106000-00014"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590701672405"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.01.088"},{"key":"e_1_2_5_21_1","first-page":"453","article-title":"Oxytocin signalling in human myometrium","volume":"395","author":"Phaneuf S","year":"1995","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_5_22_1","first-page":"302","article-title":"Aneurysms of the vein of Galen. Angiographic study and morphogenetic considerations","volume":"33","author":"Raybaud CA","year":"1987","journal-title":"Neurochirurgie"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00698838"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70543-X"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20746"},{"key":"e_1_2_5_26_1","first-page":"555","article-title":"Effect of the treatment with myo\u2010inositol plus folic acid plus melatonin in comparison with a treatment with myo\u2010inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial","volume":"14","author":"Rizzo P","year":"2010","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4871-3_35"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20112"},{"key":"e_1_2_5_29_1","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/S0140-6736(01)07104-5","article-title":"Quantifying the effect of folic acid","volume":"358","author":"Wald NJ","journal-title":"Lancet"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.22853","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.22853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T15:33:36Z","timestamp":1697643216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.22853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,28]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/bdra.22853"],"URL":"https:\/\/doi.org\/10.1002\/bdra.22853","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,28]]}}}