{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:16:07Z","timestamp":1775499367061,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND<\/jats:bold> Cyclophosphamide (CPA) is an alkylating agent widely used as an immunosuppressive agent in the treatment of several autoimmune diseases, including systemic lupus erythematosus. Its teratogenic effect has been well studied in different experimental mammalian and non\u2010mammalian animal models. In humans, 11 cases of CPA teratogenesis have been documented. <jats:bold>CASE<\/jats:bold> We present a case of a patient with Klippel\u2010Feil syndrome inadvertently exposed to CPA and prednisone in utero during the first trimester. <jats:bold>CONCLUSIONS<\/jats:bold> This case of possible cyclophosphamide embryopathy provides evidence of teratogenesis as an etiologic agent in developmental field defects such as Klippel\u2010Feil syndrome. Birth Defects Research (Part A) 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdra.23004","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T08:42:01Z","timestamp":1332837721000},"page":"249-252","source":"Crossref","is-referenced-by-count":6,"title":["Klippel\u2010Feil syndrome in a boy exposed inadvertently to cyclophosphamide during pregnancy: A case report"],"prefix":"10.1002","volume":"94","author":[{"given":"Brissia","family":"Lazalde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Grijalva\u2010Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Guerrero\u2010Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1932.02730280037009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)40851-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn065"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.65.5.1278"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016923609133384"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.2.130"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990917)86:3<237::AID-AJMG8>3.0.CO;2-V"},{"key":"e_1_2_5_9_1","first-page":"269","article-title":"An analysis of the Klippel\u2010Feil syndrome","volume":"41","author":"Erskine CA","year":"1946","journal-title":"Arch Pathol (Chic)"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00240-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(83)90007-5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03060310023005"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197456060-00018"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.13.3.246"},{"issue":"3","key":"e_1_2_5_15_1","first-page":"462","article-title":"Teratogenic effects of first\u2010trimester cyclophosphamide therapy","volume":"72","author":"Kirshon B","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160109"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770050202"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2106\/00004623-197557030-00013","article-title":"Genitourinary anomalies associated with Klippel\u2010Feil syndrome","volume":"57","author":"Moore WB","year":"1975","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1001\/jama.1984.03350180061032","article-title":"Multimodal cancer therapy for breast cancer in the first trimester of pregnancy. 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