{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T17:41:56Z","timestamp":1709833316075},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T00:00:00Z","timestamp":1340323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Homocysteine is an intermediate of the one\u2010carbon (1\u2010C) pathway and increased concentrations have been related to neural crest\u2010related congenital anomalies. The neural crest and the 1\u2010C pathway might be involved also in the etiology of Congenital Diaphragmatic Hernia (CDH). In 22 CDH and 28 control newborns and their mothers, general characteristics were obtained by standardized questionnaires. The 1\u2010C pathway intermediates total homocysteine (tHcy), S\u2010adenosylmethionine (SAM), and S\u2010adenosylhomocysteine (SAH) were determined in cord blood. Correlations between maternal and newborn factors and risk estimates were investigated by univariate and multivariable logistic regression analyses. Birth weight (2962 vs. 3418 gram; <jats:italic>p<\/jats:italic> &lt; 0.001) was lower and gestational age (270 vs. 277 days; <jats:italic>p<\/jats:italic> = 0.006) was shorter in case children. Control mothers were slightly older (32 vs. 35 year; <jats:italic>p<\/jats:italic> = 0.05). Other characteristics were comparable between case and control children and mothers. The concentrations of homocysteine, SAM and SAH, and the SAM\/SAH ratio were comparable (tHcy: 8.57 vs. 8.56 \u03bcmol\/l, <jats:italic>p<\/jats:italic> = 0.99; SAM: 152.7 vs. 157.3 nmol\/l, <jats:italic>p<\/jats:italic> = 0.76; SAH: 43.5 vs. 48.9, <jats:italic>p<\/jats:italic> = 0.26; ratio: 3.8 vs. 3.5, <jats:italic>p<\/jats:italic> = 0.50). Maternal and newborn characteristics were not correlated to the biomarker concentrations. In conclusion, the biomarkers of methylation determined in cord blood are not associated with CDH risk. Maternal and child characteristics could not predict newborn biomarker concentrations of the 1\u2010C pathway. Birth Defects Research (Part A) 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdra.23039","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T20:25:52Z","timestamp":1340396752000},"page":"557-560","source":"Crossref","is-referenced-by-count":3,"title":["Biomarkers of the one\u2010carbon pathway in association with congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"94","author":[{"given":"Leonardus W.J.E.","family":"Beurskens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst M.","family":"Schoonderwaldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Tibboel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gine P.M.","family":"Steegers\u2010Theunissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0521"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043383692"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2587"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.046995"},{"key":"e_1_2_4_6_1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/clinchem\/48.7.1100","article-title":"Perinatal reference intervals for plasma homocysteine and factors influencing its concentration","volume":"48","author":"Infante\u2010Rivard C","year":"2002","journal-title":"Clin Chem"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.6.723"},{"issue":"3","key":"e_1_2_4_8_1","first-page":"CD001056","article-title":"Periconceptional supplementation with folate and\/or multivitamins for preventing neural tube defects","author":"Lumley J","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.032904"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2008.06.014"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.01.022"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00086-X"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.109710"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2004.02.036"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01963.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20105"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20436"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23039","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T13:40:21Z","timestamp":1700574021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,22]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1002\/bdra.23039"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23039","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,22]]}}}