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Caffeine intakes from beverages (coffee, tea, and soda) and chocolate combined and by beverage type were examined. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated for subtypes of isolated LDs (no additional major anomalies) and LDs with other major anomalies separately, comparing the odds of 10 to &lt;100, 100 to &lt;200, 200 to &lt;300, and 300+ mg\/day total caffeine intake to 0 to &lt;10 mg\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All total dietary caffeine intake categories of 10 mg\/day and above were marginally associated with odds of all isolated LDs combined (aOR, 1.4\u20131.7), isolated longitudinal LDs (aOR, 1.2\u20131.6), and isolated transverse LDs (aOR, 1.3\u20131.8) compared to the lowest intake category. A dose\u2010response pattern for total dietary caffeine intake was not observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A weak increased risk of congenital LDs associated with maternal dietary caffeine consumption was observed in this study; however, risk did not vary by amount of caffeine consumed. 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