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Here, we present an in vitro embryonic mouse model of CMV\u2010infected cochleas that mimics the human sites of viral infection and associated pathology. There is a striking dysplasia\/hyperplasia in mouse CMV\u2010infected cochlear epithelium and mesenchyme, including organ of Corti hair and supporting cells and stria vascularis. This is concomitant with significant dysregulation of <jats:italic>p19<\/jats:italic>, <jats:italic>p21<\/jats:italic>, <jats:italic>p27<\/jats:italic>, and <jats:italic>Pcna<\/jats:italic> gene expression, as well as proliferating cell nuclear antigen (PCNA) protein expression. Other pathologies similar to those arising from known deafness gene mutations include downregulation of KCNQ1 protein expression in the stria vascularis, as well as hypoplastic and dysmorphic melanocytes. Thus, this model provides a relevant and reliable platform within which the detailed cell and molecular biology of CMV\u2010induced deafness may be studied. Birth Defects Research (Part A), 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdra.23105","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T10:59:57Z","timestamp":1356519597000},"page":"69-78","source":"Crossref","is-referenced-by-count":8,"title":["An in vitro mouse model of congenital cytomegalovirus\u2010induced pathogenesis of the inner ear 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