{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:04:21Z","timestamp":1767848661670,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Introduction<\/jats:title><jats:sec><jats:label\/><jats:p>Studies indicate that gastroschisis is associated with maternal age, ethnicity, and acculturation. This analysis was conducted to further define the associations between gastroschisis and parental Hispanic ethnicity and acculturation, and to determine whether such associations vary by maternal age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>This study was based on data from mothers of 753 gastroschisis cases and 6,496 control infants in the National Birth Defects Prevention Study. The relationships between gastroschisis and both parental Hispanic ethnicity and acculturation, within maternal age strata (&lt;20 versus \u226520 years at conception), were assessed using logistic regression and principal component analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The risk of gastroschisis in offspring of women &lt;20 years old was not significantly associated with parental Hispanic ethnicity or acculturation. Among mothers \u226520 years old, US\u2010born non\u2010Hispanic white parents had a lower risk of gastroschisis in offspring as compared to either US\u2010born Hispanic (odds ratios [ORs] ranging from 0.55 to 0.60) or English\u2010speaking Hispanic (ORs ranging from 0.58 to 0.65) parents. Further, compared with US born Hispanic women \u226520 years, the risk of gastroschisis was lower for Hispanic women who had lived in the US &lt;5 years (OR=0.35, 95% confidence interval [CI]: 0.17, 0.74) or who migrated to the US at \u226520 years (OR=0.47, 95% CI: 0.25, 0.88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>These results provide further evidence that gastroschisis risk is associated with ethnicity and some aspects of acculturation. Additionally, these associations were limited to the offspring of women who are <jats:styled-content>\u2265<\/jats:styled-content>20 at the time of conception. <jats:italic>Birth Defects Research (Part A) 97:538\u2010545, 2013<\/jats:italic>.  \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23140","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T12:08:00Z","timestamp":1370261280000},"page":"538-545","source":"Crossref","is-referenced-by-count":23,"title":["Hispanic ethnicity and acculturation, maternal age and the risk of gastroschisis in the national birth defects prevention study"],"prefix":"10.1002","volume":"97","author":[{"given":"Zeina G.","family":"Khodr","sequence":"first","affiliation":[{"name":"Division of Epidemiology Human Genetics and Environmental Sciences, University of Texas School of Public Health Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip 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