{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:51:43Z","timestamp":1777715503322,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:00:00Z","timestamp":1372809600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>This study explores the potential of data linkage to investigate the proportion of birth defects classified as alcohol\u2010related (ARBD) by the Institutes of Medicine (IOM) that are attributable to maternal alcohol\u2010use disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Maternal alcohol\u2010use disorder was identified using International Classification of Diseases (9th and 10th revision) codes for alcohol\u2010related diagnoses recorded on record\u2010linked Western Australian health, mental health, and\/or drug and alcohol datasets 1983 to 2007. Children of these mothers (n\u2009=\u200923,859) were compared with a randomly selected cohort of children born to mothers without an alcohol diagnosis, frequency\u2010matched by maternal age, Aboriginal status, and child's birth year (n\u2009=\u200961,370). Birth defects were identified through linkage with the Western Australian Register of Developmental Anomalies and defects with chromosomal causes were excluded. Associations between overall and individual IOM\u2010designated ARBD and a maternal alcohol\u2010related diagnosis recorded \u201cduring pregnancy\u201d or \u201cany\u201d diagnosis (before\/during\/after pregnancy) was assessed using multivariate logistic regression to generate odds ratios and 95% confidence intervals. Population\u2010attributable fractions were calculated for significant results using total population numbers.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There was a significant association between maternal alcohol\u2010related diagnoses recorded during pregnancy and ARBD (adjusted odds ratio, 3.14; 95% confidence interval, 2.49\u20133.96), with an attributable fraction of 0.57%. \u201cAny\u201d maternal alcohol diagnosis demonstrated a higher attributable fraction for ARBD (1.53%), with the highest attributable fractions for microcephaly (7.31%), ptosis (3.75%), atrial septal defect (2.86%), and conotruncal heart defects (2.01%).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Research using linked, population\u2010based administrative health data has the potential to advance knowledge of ARBD. Routine collection and recording of alcohol use during pregnancy for all pregnant women is required and would enhance this methodology. <jats:italic>Birth Defects Research (Part A) 97:497\u2013504, 2013<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23142","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T11:32:33Z","timestamp":1372851153000},"page":"497-504","source":"Crossref","is-referenced-by-count":33,"title":["Exploring the potential to use data linkage for investigating the relationship between birth defects and prenatal alcohol exposure"],"prefix":"10.1002","volume":"97","author":[{"given":"Colleen M.","family":"O'Leary","sequence":"first","affiliation":[{"name":"Centre for Population Health Research Curtin University Perth Western Australia"},{"name":"Division of Population Sciences Telethon Institute for Child Health Research Centre for Child Health Research University of Western Australia West Perth Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Discipline of Pediatrics and Child Health University of Sydney Medical School Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Nassar","sequence":"additional","affiliation":[{"name":"Kolling Institute of Medical Research Sydney University Royal North Shore Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Bower","sequence":"additional","affiliation":[{"name":"Division of Population Sciences Telethon Institute for Child Health Research Centre for Child Health Research University of Western Australia West Perth Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/35.4.400"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.6.712"},{"key":"e_1_2_6_4_1","volume-title":"Report of the birth defects registry of Western Australia; 1980\u20132008","author":"Bower C","year":"2009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9926(200101)63:1<23::AID-TERA1004>3.0.CO;2-S"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2000.00575.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.1999.tb01299.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2002.10617.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2007.00105.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10087"},{"key":"e_1_2_6_11_1","volume-title":"Fetal alcohol syndrome: guidelines for referral and diagnosis","year":"2004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040302"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00303.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2003.00281.x"},{"key":"e_1_2_6_15_1","volume-title":"The quantification of drug\u2010caused morbidity and mortality in Australia","author":"English DR","year":"1995"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/10826081003682172"},{"key":"e_1_2_6_17_1","volume-title":"Twenty\u2010second Annual Report of the Western Australian Midwives' Notification System","author":"Gee V","year":"2006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20562"},{"key":"e_1_2_6_19_1","volume-title":"A short\u2010course with Professor D'Arcy Holman","author":"Holman CD","year":"2006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.1999.tb01297.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0259"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2779"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(03)00003-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2006.05.011"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12167"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03333.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0256"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2011.04201.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.2005.tb00251.x"},{"key":"e_1_2_6_30_1","unstructured":"ProudfootH.2006.DSM\u2010IV Alcohol use disorders in Australia: validity prevalence and treatment seeking. PhD thesis. University of New South Wales."},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20823"},{"key":"e_1_2_6_32_1","first-page":"203","article-title":"Clinical profile and revalence of fetal alcohol syndrome in an isolated community in British Columbia","volume":"137","author":"Robinson CG","year":"1987","journal-title":"CMAJ"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34276"},{"key":"e_1_2_6_34_1","volume-title":"Diagnosis, epidemiology, prevention, and treatment","author":"Stratton K","year":"1996"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3506(05)80283-5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00146368"},{"key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF03334972","article-title":"Risk factors for conal malformations of the heart","volume":"8","author":"Tikkanen J","year":"1992","journal-title":"Eur J Epidemiol"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23142","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:29:25Z","timestamp":1696602565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/bdra.23142"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23142","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}