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This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Through a case\u2013control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999\u20132003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63\u20131.56 and 2.44; 95% confidence interval, 1.08\u20135.53 among breech presentation infants. Probabilistic bias analysis supported these findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>No association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted. <jats:italic>Birth Defects Research (Part A) 97:641\u2013648, 2013<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23143","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T18:53:12Z","timestamp":1374778392000},"page":"641-648","source":"Crossref","is-referenced-by-count":4,"title":["Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003"],"prefix":"10.1002","volume":"97","author":[{"given":"Erin K.","family":"Sauber\u2010Schatz","sequence":"first","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health Department of Epidemiology Pittsburgh Pennsylvania"},{"name":"Centers for Disease Control and Prevention National Center for Injury Research and Control Division of Unintentional Injury Prevention Atlanta Georgia (Currently)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Bodnar","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health Department of Epidemiology Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold B.","family":"Weiss","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health Department of Epidemiology Pittsburgh Pennsylvania"},{"name":"University of Otago School of Medicine Department of Preventive and Social Medicine Injury Prevention Research Unit Dunedin New Zealand (Currently)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Wilson","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health Department of Biostatistics Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Pearlman","sequence":"additional","affiliation":[{"name":"University of Michigan Department of Surgery and Department of Obstetrics and Gynecology Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Markovic","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health Department of Epidemiology Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(87)80418-3"},{"key":"e_1_2_5_3_1","first-page":"1","article-title":"Deaths: leading causes for 1999","volume":"49","author":"Anderson RN","year":"2001","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_5_4_1","first-page":"656","article-title":"An unexpected fetal outcome following a severe maternal motor vehicle accident","volume":"84","author":"Ankuist KW","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4065\/75.12.1243"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb13920.x"},{"key":"e_1_2_5_7_1","first-page":"375","article-title":"Fetal skull fracture and brain injury after a maternal automobile accident","volume":"32","author":"Bowdler N","year":"1987","journal-title":"A case report. 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