{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:40:50Z","timestamp":1770295250077,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Cephalothoracopagus twinning is extremely rare, and it is characterized by fusion of the head and thorax, two separate spines, pelves, and fore\u2010 and hindlimbs. <jats:bold>CASE:<\/jats:bold> In this case study, we describe cephalothoracopagus twinning in an embryonic mouse displaying a large but exencephalic head, median facial cleft, a single eye, and a second hindbrain rotated roughly 90<jats:sup>\u00b0<\/jats:sup> from a second spinal cord. There is a bony connection joining the clavicles, resulting in merged asternal thoracic cavities containing two hearts and four lungs. The abdominal cavities contain double caudal digestive tract structures, but a single esophagus and stomach.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>There are several proposed theories regarding the mechanism of spontaneous conjoined twinning; however, the specific mechanisms are still largely unknown. In this report, we highlight the morphological features in a murine example of cephalothoracopagus twinning, furthering our understanding of this rare occurrence while also demonstrating developmental morphogenesis consistent with that reported for human conjoined twins. <jats:italic>Birth Defects Research (Part A) 97:421\u2013424, 2013<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23151","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T05:28:41Z","timestamp":1371101321000},"page":"421-424","source":"Crossref","is-referenced-by-count":4,"title":["Case of cephalothoracopagus conjoined twinning in an embryonic mouse"],"prefix":"10.1002","volume":"97","author":[{"given":"Thomas E.","family":"Hynd","sequence":"first","affiliation":[{"name":"Department of Anatomy Biochemistry and Physiology John A. Burns School of Medicine, University of Hawaii Honolulu Hawaii"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cadie L.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Anatomy Biochemistry and Physiology John A. Burns School of Medicine, University of Hawaii Honolulu Hawaii"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Lozanoff","sequence":"additional","affiliation":[{"name":"Department of Anatomy Biochemistry and Physiology John A. Burns School of Medicine, University of Hawaii Honolulu Hawaii"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.105"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098587701400514"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/019262337700500402"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230202"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.06.005"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004040050216"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10195"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/276707a0"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701228438"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.07.002"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2009.00944.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10042"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510020061009"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90417-0"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(2000)13:1<36::AID-CA5>3.0.CO;2-3"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.10.1307"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88418-4_24"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T22:19:29Z","timestamp":1696630769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1002\/bdra.23151"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23151","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}