{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:15:54Z","timestamp":1772770554991,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The teratogenic effects of antenatal exposure of antithyroid drugs, carbimazole and methimazole have been well reported in the literature. These comprise of typical facial features and a wide variety of malformations such as choanal atresia, tracheo\u2010esophageal anomalies, congenital heart disease and ectodermal defects. However, the longitudinal studies have failed to establish the consistent teratogenicity of these drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASES<\/jats:title><jats:p>we report here two siblings with physical features consistent with carbimazole\/methimazole embryopathy. We also describe previously unreported minor dental anomalies in these siblings with antenatal exposure of carbimazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Generally, only a small proportion of prenatally exposed children have the typical manifestations, and the presence in siblings supports a possible hereditary susceptibility to carbimazole\/ methimazole embryopathy. This highlights the importance of recognizing this diagnosis before a subsequent pregnancy. <jats:italic>Birth Defects Research (Part A) 97:755\u2013758, 2013<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23200","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T15:56:08Z","timestamp":1383753368000},"page":"755-758","source":"Crossref","is-referenced-by-count":10,"title":["Carbimazole\/methimazole embryopathy in siblings: A possible genetic susceptibility"],"prefix":"10.1002","volume":"97","author":[{"given":"Himanshu","family":"Goel","sequence":"first","affiliation":[{"name":"Hunter Genetics Waratah NSW Australia"},{"name":"University of Newcastle Callaghan NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Dudding","sequence":"additional","affiliation":[{"name":"Hunter Genetics Waratah NSW Australia"},{"name":"University of Newcastle Callaghan NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20668"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32497"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10458"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcq248"},{"issue":"2011","key":"e_1_2_5_6_1","first-page":"235130","article-title":"Suspected spontaneous reports of birth defects in the UK associated with the use of carbimazole and propylthiouracil in pregnancy","author":"Bowman P","year":"2011","journal-title":"J Thyroid Res"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03019.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990305)83:1<43::AID-AJMG8>3.0.CO;2-C"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1072"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30418"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33705"},{"key":"e_1_2_5_12_1","first-page":"505","article-title":"Comparative bioavailability of carbimazole and methimazole","volume":"21","author":"Jansson R","year":"1983","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.2.947-a"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2010.07.001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001002)94:4<338::AID-AJMG13>3.0.CO;2-6"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050117"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1984.tb00119.x"},{"key":"e_1_2_5_18_1","first-page":"282","article-title":"Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole","volume":"46","author":"Mujtaba Q","year":"1975","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320440216"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01572.x"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23200","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T23:30:46Z","timestamp":1696548646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1002\/bdra.23200"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23200","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}