{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:17:25Z","timestamp":1790252245675,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold>: Although genome\u2010wide association studies have identified several susceptibility loci for nonsyndromic cleft lip with or without cleft palate (NSCL\/P) in populations around the world, the role of most loci is unknown in the highly heterogeneous Brazilian population. <jats:bold>Methods<\/jats:bold>: To determine the association of 7 markers that showed genome\u2010wide significant association in Brazilians with NSCL\/P, we conducted a structured association study conditioned upon the individual ancestry proportions to evaluate markers at 1p36 (rs742071), 2p21 (rs7590268), 3p11.1 (rs7632427), 8q21.3 (rs12543318), 13q31.1 (rs8001641), 15q22.2 (rs1873147), and 17q22 (rs227731) in 505 patients with NSCL\/P and 594 healthy controls recruited from 2 different geographical regions of Brazil. The polymorphisms were genotyped by TaqMan 5\u2032\u2010exonuclease allelic discrimination assay, and each sample was independently typed for 40 biallelic short insertion\/deletion markers to characterize the genomic ancestry. <jats:bold>Results<\/jats:bold>: After Bonferroni correction for multiple tests, significant associations with NSCL\/P were observed for rs742071, rs1873147, and rs227731. However, the frequency of the risk alleles varied between the geographical regions, according to the proportions of European and African genomic ancestry. The group enriched by European ancestry showed significant association with rs227731 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), whereas the group with high African ancestry was significantly associated with rs1873147 polymorphism (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). The significant association with rs742071 was only detected in the combined sample (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). <jats:bold>Conclusion<\/jats:bold>: The findings of the present study revealed the associations of 1p36 (rs742071), 15q22 (rs1873147), and 17p22 (rs227731) with NSCL\/P in the Brazilian population, and further confirmed that the genetic heterogeneity of NSCL\/P may be related to the different ethnic background of the affected individuals. <jats:italic>Birth Defects Research (Part A) 100:36\u201342, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdra.23204","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T08:29:43Z","timestamp":1390292983000},"page":"36-42","source":"Crossref","is-referenced-by-count":28,"title":["Analysis of susceptibility polymorphisms for nonsyndromic cleft lip with or without cleft palate in the Brazilian population"],"prefix":"10.1002","volume":"100","author":[{"given":"Sibele Nascimento","family":"de Aquino","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis School of Dentistry State University of Campinas Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Camila","family":"Messetti","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis School of Dentistry State University of Campinas Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuchi","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica Dentistry Course Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Borges","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica Dentistry Course Salvador Bahia 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