{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:22:23Z","timestamp":1759479743723},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Background:<\/jats:title><jats:p>Maternal tea consumption was reported to increase the risk of fetal neural tube defects (NTDs). Catechol\u2010O\u2010methyltransferase (COMT) may be involved in the metabolism of polyphenolic methylation of tea, thus influence the risk of fetal NTDs. <jats:bold>Methods:<\/jats:bold> A total of 576 fetuses or newborns with NTDs and 594 healthy newborns were included in the case\u2013control study. Information on maternal tea consumption, sociodemographic characteristics, reproductive history, and related behavior was collected through face\u2010to\u2010face interviews. Maternal blood samples were collected to examine polymorphisms in <jats:italic>COMT<\/jats:italic>, and the possible interaction of <jats:italic>COMT<\/jats:italic> and tea consumption was analyzed. <jats:bold>RESULTS:<\/jats:bold> After controlling for potential confounders, homozygotes of rs737865 showed an elevated risk for total NTDs (odds ratio [OR]\u2009=\u20092.04, 95% confidence interval [CI], 1.24\u20133.35) and for the anencephaly subtype (OR\u2009=\u20091.99, 95% CI, 1.17\u20133.39). The CC genotype of rs4633 was positively associated with the overall risk of NTDs (OR\u2009=\u20093.66, 95% CI, 1.05\u201312.83). Heterozygotes for rs4680 were associated with a decreased risk of spina bifida (OR\u2009=\u20090.71, 95% CI, 0.51\u20130.98). The <jats:italic>COMT<\/jats:italic> rs4680 A allele was negatively related with the risk of spina bifida, with adjusted OR\u2009=\u20090.64 (95% CI, 0.45\u20130.89). An interaction between tea consumption (1 to 2 cups\/day) and the rs4680AA\/AG genotype was found in the spina bifida subtype (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u2009=\u2009.08). <jats:bold>Conclusion:<\/jats:bold> Several <jats:italic>COMT<\/jats:italic> variants were associated with elevated risk of NTDs in a Chinese population. Maternal tea consumption may be associated with an increased risk for fetal NTDs in genetically susceptible subgroups. <jats:italic>Birth Defects Research (Part A) 100:22\u201329, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdra.23208","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T08:29:43Z","timestamp":1390292983000},"page":"22-29","source":"Crossref","is-referenced-by-count":10,"title":["Association between maternal <i>COMT<\/i> gene polymorphisms and fetal neural tube defects risk in a Chinese population"],"prefix":"10.1002","volume":"100","author":[{"given":"Jufen","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health; Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health; Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunting","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health; Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health; Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health; Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health; Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health; Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongwei","family":"Ye","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health; Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiguo","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health\/Ministry of Health Key Laboratory of Reproductive Health; Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9177-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33755"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513591003632183"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20471"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(00)00144-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22155"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20563"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591577406700513"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1160\/TH07-05-0381","article-title":"Catechol\u2010O\u2010methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk","volume":"98","author":"Gellekink H","year":"2007","journal-title":"Thromb Haemost"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20397"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2012.10.015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20248"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23108"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2012.03.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2013.04.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2007.06.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2206"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-13-62"},{"key":"e_1_2_7_22_1","first-page":"108","article-title":"Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease","volume":"29","author":"Rissling","year":"2006","journal-title":"Sleep"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30700"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23025"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31821b4526"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:38:24Z","timestamp":1696621104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,31]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/bdra.23208"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23208","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,31]]}}}