{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:35:26Z","timestamp":1779233726896,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Nonsyndromic cleft lip with or without cleft palate (NSCL\/P) is among the most frequently occurring congenital malformations worldwide. The number of genetic loci identified as being involved in NSCL\/P etiology was recently increased by a large genome\u2010wide meta\u2010analysis of European and Asian samples. This meta\u2010analysis confirmed all six previously recognized genetic susceptibility loci and identified six novel ones. <jats:bold>Methods:<\/jats:bold> To investigate which of these 12 loci contribute to NSCL\/P risk in an independent sample of distinct ethnicity, we performed a case\u2013control association analysis in a sample of the Mesoamerican population. A total of 153 individuals with NSCL\/P (cases) and 337 unaffected controls were included. Top single\u2010nucleotide polymorphisms (SNPs) at 8 of the 12 loci (1p22.1, 1p36, 2p21, 3p11.1, 8q21.3, 13q31.1, 15q22, and 20q12) were analyzed using mass spectroscopy and restriction\u2010length\u2010fragment polymorphism analyses. In a previous study, we had analyzed the remaining four NSCL\/P susceptibility regions (<jats:italic>IRF6<\/jats:italic>, 8q24, 10q25, and 17q22) in the same sample. <jats:bold>Results:<\/jats:bold> Single\u2010marker association analyses applying allelic, dominant, and recessive models revealed nominal significant associations for four of the eight loci, with two additional loci showing at least a trend of association in the hypothesized direction. <jats:bold>Conclusion:<\/jats:bold> In combination with results from our previous study using the same sample, our data suggest that the majority of the known NSCL\/P susceptibility regions identified to date also confer risk for this malformation in the Mesoamerican population. <jats:italic>Birth Defects Research (Part A) 100:43\u201347, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdra.23209","type":"journal-article","created":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T11:02:44Z","timestamp":1388487764000},"page":"43-47","source":"Crossref","is-referenced-by-count":15,"title":["Evaluating eight newly identified susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a Mesoamerican population"],"prefix":"10.1002","volume":"100","author":[{"given":"Kerstin U.","family":"Ludwig","sequence":"first","affiliation":[{"name":"Institute of Human Genetics University of Bonn Bonn Germany"},{"name":"Department of Genomics Life and Brain Center, University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Wahle","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn Bonn Germany"},{"name":"Department of Genomics Life and Brain Center, University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Reutter","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn Bonn Germany"},{"name":"Department of Neonatology Children's Hospital, University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Paredes\u2010Zenteno","sequence":"additional","affiliation":[{"name":"Hospital Regional de Tuxtla Guti\u00e9rrez Tuxtla Guti\u00e9rrez Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio G.","family":"Mu\u00f1oz\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Esquipulas, San Crist\u00f3bal de las Casas  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocio","family":"Ortiz\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine School of Medicine Universidad Autonoma de Nuevo Leon Monterrey Mexico"},{"name":"Centro de Investigaci\u00f3n y Desarrollo en Ciencias de la Salud Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne C.","family":"B\u00f6hmer","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn Bonn Germany"},{"name":"Department of Genomics Life and Brain Center, University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Tessmann","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn Bonn Germany"},{"name":"Department of Genomics Life and Brain Center, University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Nowak","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus M.","family":"N\u00f6then","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn Bonn Germany"},{"name":"Department of Genomics Life and Brain Center, University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Knapp","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry Informatics and Epidemiology, University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Rojas\u2010Martinez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine School of Medicine Universidad Autonoma de Nuevo Leon Monterrey Mexico"},{"name":"Centro de Investigaci\u00f3n y Desarrollo en Ciencias de la Salud Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Mangold","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn Bonn 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