{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:44:08Z","timestamp":1761561848773},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors. <jats:bold>Methods:<\/jats:bold> Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population\u2010based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.3 million births. Analysis was performed by estimated month of conception. Analyses were performed for 86 congenital anomaly subgroups, including a combined subgroup of congenital anomalies previously associated with influenza. <jats:bold>Results:<\/jats:bold> We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and\/or dysplasia (April, 12%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed. <jats:bold>Conclusion:<\/jats:bold> We have confirmed previously described seasonality for congenital cataract and hip dislocation and\/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor in the seasonality of congenital anomalies. Birth Defects Research (Part A) 100:260\u2013269, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23231","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T07:56:44Z","timestamp":1395043004000},"page":"260-269","source":"Crossref","is-referenced-by-count":13,"title":["Seasonality of congenital anomalies in Europe"],"prefix":"10.1002","volume":"100","author":[{"given":"Johannes Michiel","family":"Luteijn","sequence":"first","affiliation":[{"name":"Institute of Nursing Research\/School of Nursing University of Ulster Jordanstown Campus Newtownabbey United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Dolk","sequence":"additional","affiliation":[{"name":"Institute of Nursing Research\/School of Nursing University of Ulster Jordanstown Campus Newtownabbey United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Claude","family":"Addor","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larraitz","family":"Arriola","sequence":"additional","affiliation":[{"name":"Public Health Division of Gipuzkoa Instituto BIO\u2010Donostia, Basque Government, CIBER Epidemiolog\u00eda y Salud P\u00fablica \u2010 CIBERESP  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg","family":"Barisic","sequence":"additional","affiliation":[{"name":"Children's Hospital Zagreb Medical School University of Zagreb  Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Institute of Clinical Physiology  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Calzolari","sequence":"additional","affiliation":[{"name":"IMER Registry \u2010 Azienda Ospedaliero\u2010Universitaria di Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Draper","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Leicester  Leicester United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester","family":"Garne","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hospital Lillebaelt  Kolding Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Gatt","sequence":"additional","affiliation":[{"name":"Malta Congenital Anomalies Registry Department of Health Information  Guardamangia Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Haeusler","sequence":"additional","affiliation":[{"name":"Medical University of Graz  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Khoshnood","sequence":"additional","affiliation":[{"name":"INSERM U953 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob","family":"McDonnell","sequence":"additional","affiliation":[{"name":"Health Service Executive Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Nelen","sequence":"additional","affiliation":[{"name":"Provinciaal Instituut voor Hygiene Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"O'Mahony","sequence":"additional","affiliation":[{"name":"Health Service Executive Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmel","family":"Mullaney","sequence":"additional","affiliation":[{"name":"Health Service Executive Kilkenny Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Queisser\u2010Luft","sequence":"additional","affiliation":[{"name":"University Medical Center of the Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Rankin","sequence":"additional","affiliation":[{"name":"Institute of Health &amp; 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