{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T07:52:20Z","timestamp":1720079540465},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Background: Limb\u2010body wall defect is a rare condition characterized by a combination of large and complex defects of the ventral thorax and abdominal wall with craniofacial and limb anomalies. Methods: The aim of this study was to describe the experience of our fetal medicine service, a reference from Southern Brazil, with prenatally diagnosed patients with a limb\u2010body wall defect in a 3 years period. Only patients who fulfilled the criteria suggested by Hunter et al. (2011) were included in the study. Clinical data and results of radiological and cytogenetic evaluation were collected from their medical records. Results: Our sample was composed of 8 patients. Many of their mothers were younger than 25 years (50%) and in their first pregnancy (62.5%). It is noteworthy that one patient was referred due to suspected anencephaly and another due to a twin pregnancy with an embryonic sac. Craniofacial defects were verified in three patients (37.5%), thoracic\/abdominal abnormalities in 6 (75%) and limb defects in eight (100%). Congenital heart defects were observed in five patients (62.5%). One of them presented a previously undescribed complex heart defect. Conclusion: The results disclosed that complementary exams, such as MRI and echocardiography, are important to better define the observed defects. Some of them, such as congenital heart defects, may be more common than previously reported. This definition is essential for the proper management of the pregnancy and genetic counseling of the family. The birth of these children must be planned with caution and for the prognosis a long survival possibility, despite unlikely and rare, must be considered. <jats:italic>Birth Defects Research (Part A) 100:739\u2013749, 2014<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdra.23266","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T15:28:59Z","timestamp":1403882939000},"page":"739-749","source":"Crossref","is-referenced-by-count":11,"title":["Limb\u2010body wall defect: Experience of a reference service of fetal medicine from Southern Brazil"],"prefix":"10.1002","volume":"100","author":[{"given":"Ana C.","family":"Gazolla","sequence":"first","affiliation":[{"name":"Ginecology and Obstetrics Hospital Materno Infantil Presidente Vargas (HMIPV) Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 C.","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Fetal Medicine HMIPV Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A.B.","family":"Telles","sequence":"additional","affiliation":[{"name":"Fetal Medicine HMIPV Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosilene da S.","family":"Betat","sequence":"additional","affiliation":[{"name":"Fetal Medicine HMIPV Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayara A.","family":"Romano","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology HMIPV Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Marshall","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology HMIPV Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"Gobatto","sequence":"additional","affiliation":[{"name":"Graduation in Medicine Universidade Luterana do Brasil (ULBRA) Canoas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"de H. Bicca","sequence":"additional","affiliation":[{"name":"Graduation in Medicine Universidade Luterana do Brasil (ULBRA) Canoas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila P.","family":"Arcolini","sequence":"additional","affiliation":[{"name":"Graduation in Medicine Universidade Luterana do Brasil (ULBRA) Canoas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds K.V.","family":"Dal Pai","sequence":"additional","affiliation":[{"name":"Graduation in Medicine Universidade Luterana do Brasil (ULBRA) Canoas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology HMIPV Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano V.","family":"Targa","sequence":"additional","affiliation":[{"name":"Radiology HMIPV Porto Alegre RS Brazil"},{"name":"Tomocl\u00ednica Canoas RS 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