{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T22:00:42Z","timestamp":1771711242448,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000008","name":"Health Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000008","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The difficulty many birth defects registries have in identifying early pregnancy terminations can lead to significant underreporting of certain types of malformations. This study was designed to determine the potential benefit of using maternal ICD\u20109 codes relating to management of pregnancy due to fetal anomaly in surveillance of central nervous system (CNS) defects (655.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women assigned the ICD\u20109\/ICD\u20109\u2010CM (henceforth termed ICD\u20109) code 655.0 between 1990 and 2000 were ascertained from two administrative health databases in Manitoba, Canada, one relating to maternal serum screening and one based on hospital discharges. Information was collected on the type of CNS defect identified and whether it was isolated or associated with other anomalies. The relationship of these variables to pregnancy outcome and its potential impact on surveillance for these types of defects was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neural tube defects were the most common finding (67%) identified in the fetuses\/infants of women assigned code 655.0, followed by hydrocephaly (20%) and Dandy\u2010Walker anomaly (6%), but the proportion of neural tube defect cases declined after food fortification with folic acid. Termination of pregnancy occurred in \u223c50% of neural tube defect cases, 18% before 20 weeks of gestation, but was rare for other CNS defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The maternal ICD\u20109 code 655.0 had a very high (97%) positive predictive value for identifying fetuses with a CNS defect; 655.00 was particularly effective in identifying neural tube defects pregnancies terminated before 20 weeks gestation that would be difficult to ascertain, especially by passive surveillance systems using infant related data alone. Birth Defects Research (Part A) 100:848\u2013851, 2014.  \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23287","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T07:49:18Z","timestamp":1406706558000},"page":"848-851","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy outcome in women assigned an ICD\u20109\/ICD\u20109\u2010CM 655.0 code \u201ccentral nervous system malformation in fetus affecting management of pregnancy\u201d: Can these codes aid in surveillance for central nervous system defects?"],"prefix":"10.1002","volume":"100","author":[{"given":"Jane A","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Medical Genetics University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Canadian Institute for Health Information.2009. ICD\u201010\u2010CA Tenth Edition Volume 1 Tabular list p628. Available at:http:\/\/www.cihi.ca\/cihi\u2010ext\u2010portal\/pdf\/internet\/icd_10_ca_vol1_2009_en. Accessed 11 June 2014."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067103"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03404123"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.12.1561"},{"key":"e_1_2_6_6_1","first-page":"52","article-title":"Determinants of parental decision to abort or continue after non\u2010aneuploid ultrasound\u2010detected fetal abnormalities","volume":"80","author":"Pryde PG","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_7_1","unstructured":"Public Health Agency of Canada.2009. Systems and Data Sources for Congenital Anomalies Surveillance in Canada. Available at:http:\/\/www.phac\u2010aspc.gc.ca\/ccasn\u2010csac\/publications\/surveillance_systems\u2010eng.php (last updated 27 May 2009). Accessed May 14 2014."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01673-8"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23287","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T12:20:29Z","timestamp":1694521229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,30]]},"references-count":7,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/bdra.23287"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23287","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,30]]}}}