{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T11:52:53Z","timestamp":1719921173933},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Center for Birth Defects Research and Prevention in the Massachusetts Department of Public Health","award":["213820210974"],"award-info":[{"award-number":["213820210974"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The prenatal diagnosis procedure chorionic villus sampling is associated with increased risk of vascular disruption limb defects. Some studies have suggested that these defects are more common among infants born to women 35 years and older while other studies have shown a correlation with younger mothers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All infants with vascular disruption defects were identified in the Active Malformations Surveillance Program at Brigham and Women's Hospital in the years 1972\u20131974, 1979\u20132011. We compared the rate of occurrence of infants with vascular limb defects among women in theses age groups: \u226419, 20 to 34, and \u226535 years to the rate of occurrence of infants with preaxial polydactyly, adjusting for race. Infants with an identifiable cause of their defects were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>106 infants with vascular disruption defects and 67 with preaxial polydactyly were identified. Seventeen percent of the infants with vascular disruption defects and 25% of the infants with preaxial polydactyly were born to women 35 and older (<jats:italic>p<\/jats:italic>\u2009=\u20090.23). In contrast, 16% of the infants with vascular disruption defects were born to young mothers (\u226419 years) compared with 6.0% of the mothers of infants with preaxial polydactyly (adjusted odds ratio vs. 35+ years\u2009=\u20095.3, 95% confidence interval 1.4\u201321, <jats:italic>p<\/jats:italic>\u2009=\u20090.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women 35 years old or older did not have increased risk for having a child with vascular disruption defects, but these defects were more common among infants of young (\u226419) mothers, compared with the preaxial polydactyly group. Birth Defects Research (Part A) 100:760\u2013763, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23294","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T11:13:10Z","timestamp":1409656390000},"page":"760-763","source":"Crossref","is-referenced-by-count":4,"title":["Vascular limb defects and maternal age"],"prefix":"10.1002","volume":"100","author":[{"given":"Hanah Z.","family":"Nasri","sequence":"first","affiliation":[{"name":"Medical Genetics Unit MassGeneral Hospital for Children Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Noel","family":"Westgate","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit MassGeneral Hospital for Children Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Macklin","sequence":"additional","affiliation":[{"name":"The Biostatistics Center Massachusetts General Hospital; Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis B.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit MassGeneral Hospital for Children Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320230405"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1542\/peds.91.5.989","article-title":"Spectrum of limb disruption defects associated with chorionic villus sampling","volume":"91","author":"Burton BK","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91374-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019605-199901000-00010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33999"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10078"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470733"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420510408"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70516-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e318193d61a"},{"key":"e_1_2_7_12_1","volume-title":"Common malformations","author":"Holmes LB","year":"2012"},{"key":"e_1_2_7_13_1","first-page":"143","article-title":"Congenital constriction band syndrome: pathophysiology and treatment","volume":"66","author":"Light TR","year":"1993","journal-title":"Yale J Biol Med"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019605-199810000-00001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)76507-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970331)69:3<237::AID-AJMG5>3.0.CO;2-I"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970331)69:3<232::AID-AJMG3>3.0.CO;2-N"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320530212"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901053200104"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","unstructured":"OlneyRS KhouryMJ AloCJ et al.1995.Increased risk for transverse digital deficiency after chorionic villus sampling: results of the United States Multistate Case\u2010Control Study 1988\u20131992.Teratology51:20\u201329.","DOI":"10.1002\/tera.1420510104"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90213-Z"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-199911000-00001"},{"key":"e_1_2_7_23_1","first-page":"219","article-title":"Fetal vascular disruptions: mechanisms and some resulting birth defects","volume":"10","author":"Allen MI","year":"1981","journal-title":"Pediatr Ann"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20102"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20524"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23294","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:55:48Z","timestamp":1696607748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,2]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/bdra.23294"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23294","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,2]]}}}