{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:33:29Z","timestamp":1760549609003},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"RMC Fetal Medicine Clinic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple congenital abnormalities are caused by chromosomal aberrations, mutant major genes and teratogens. A minor proportion of these patients are identified as syndromes but the major part belonging to the group of unclassified multiple CAs (UMCAs). The main objective of this study was to evaluate the maternal age and birth order in pregnant women who had offspring affected with UMCA. The strong association between numerical chromosomal aberrations, e.g., Down syndrome and advanced maternal age is well\u2010known and tested here.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Hungarian Case\u2010Control Surveillance of Congenital Abnormalities, 1980 to 1996, yielded a large population\u2010based national data set with 22,843 malformed newborns or fetuses (\u201cinformative cases\u201d) included 1349 UMCA cases with their 2407 matched controls. Case\u2010control comparison of maternal age and birth order was made for cases with UMCA, stratified by component numbers and their controls. In addition, 834 cases with Down syndrome were compared to 1432 matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The well\u2010known advanced maternal age with the higher risk for Down syndrome was confirmed. The findings of the study suggest that the young age of mothers associates with the higher risk of UMCA, in addition birth order 4 or more associates with the higher risk for UMCA with 2 and 3 component CAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study was the first to analyze the possible maternal and birth order effect for cases with UMCA, and the young age and higher birth order associated with a higher risk for UMCA. Birth Defects Research (Part A) 103:67\u201375, 2015 \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23304","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T06:24:37Z","timestamp":1410848677000},"page":"67-75","source":"Crossref","is-referenced-by-count":7,"title":["Distribution of maternal age and birth order groups in cases with unclassified multiple congenital abnormalities according to the number of component abnormalities: A national population\u2010based case\u2010control study"],"prefix":"10.1002","volume":"103","author":[{"given":"Gyula","family":"Csermely","sequence":"first","affiliation":[{"name":"RMC Fetal Medicine Center Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E.","family":"Czeizel","sequence":"additional","affiliation":[{"name":"Foundation for the Community Control of Hereditary Diseases Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Veszpr\u00e9mi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"600","volume-title":"Influences On Human Development","author":"Altus WD","year":"1972"},{"key":"e_1_2_6_3_1","first-page":"112","article-title":"Hypospadias \u2013 genetics, epidemiology and other possible aetiological influences","volume":"39","author":"Angerpointer TA","year":"1984","journal-title":"Zeitschrift Kinderchir"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91306-F"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.918946"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.05.035"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199705)55:5<299::AID-TERA1>3.0.CO;2-V"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740330902916459"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.02.018"},{"key":"e_1_2_6_10_1","volume-title":"Multiple congenital abnormalities","author":"Czeizel AE","year":"1988"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6876.499"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1032"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.766"},{"key":"e_1_2_6_14_1","first-page":"179","article-title":"Smoking and alcohol drinking during pregnancy. 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