{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:28:29Z","timestamp":1783114109047,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about population\u2010based maternal, child, and system characteristics associated with high hospital resource use for children with orofacial clefts (OFC) in the US.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a statewide, population\u2010based, retrospective observational study of children with OFC born between 1998 and 2006, identified by the Florida Birth Defects Registry whose records were linked with longitudinal hospital discharge records. We stratified the descriptive results by cleft type [cleft lip with cleft palate, cleft lip, and cleft palate] and by isolated versus nonisolated OFC (accompanied by other coded major birth defects). We used Poisson regression to analyze associations between selected characteristics and high hospital resource use (\u226590<jats:sup>th<\/jats:sup> percentile of estimated hospitalized days and inpatient costs) for birth, postbirth, and total hospitalizations initiated before age 2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Our analysis included 2,129 children with OFC. Infants who were born low birth weight (&lt;2500 grams) were significantly more likely to have high birth hospitalization costs for CLP (adjusted prevalence ratio: 1.6 [95% confidence interval: 1.0\u20132.7]), CL (adjusted prevalence ratio: 3.0 [95% confidence interval: 1.1\u20138.1]), and CP (adjusted prevalence ratio: 2.3 [95% confidence interval: 1.3\u20134.0]). Presence of multiple birth defects was significantly associated with a three\u2010 to eleven\u2010fold and a three\u2010 to nine\u2010fold increase in the prevalence of high costs and number of hospitalized days, respectively; at birth, postbirth before age 2 years and overall hospitalizations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with cleft palate had the greatest hospital resources use. Additionally, the presence of multiple birth defects contributed to greater inpatient days and costs for children with OFC. Birth Defects Research (Part A) 103:127\u2013143, 2015 \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23356","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T02:33:11Z","timestamp":1425004391000},"page":"127-143","source":"Crossref","is-referenced-by-count":18,"title":["Factors associated with high hospital resource use in a population\u2010based study of children with orofacial clefts"],"prefix":"10.1002","volume":"103","author":[{"given":"Hilda","family":"Razzaghi","sequence":"first","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta Georgia"},{"name":"Oak Ridge Institute for Science and Education Oak Ridge Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Dawson","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Grosse","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Allori","sequence":"additional","affiliation":[{"name":"Duke Cleft and Craniofacial Center; Division of Plastic, Maxillofacial and Oral Surgery; Duke University Hospital and Children's Health Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell S.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Birth Defects Surveillance Program, Department of Community and Family Health, College of Public Health University of South Florida Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Olney","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Correia","sequence":"additional","affiliation":[{"name":"Florida Birth Defects Registry, Bureau of Epidemiology Division of Disease Control and Health Protection, Florida Department of Health Tallahassee Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia H.","family":"Cassell","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318208d25e"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181f95af3"},{"key":"e_1_2_7_4_1","unstructured":"Agency for Healthcare Research and Quality (AHRQ).2013. 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