{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:28:40Z","timestamp":1790166520887,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"crossref","award":["OTKA 112829"],"award-info":[{"award-number":["OTKA 112829"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Background: In most patients affected by isolated oesophageal atresia (IOA) the etiology is largely unknown. Thus, the aim of this study was to analyze potential risk factors in mothers. Methods: The study samples included 221 cases with IOA, 356 matched and 38,151 population controls without any defect in the population\u2010based dataset of the Hungarian Case\u2013Control Surveillance of Congenital Abnormalities, 1980 to 1996. Only those exposures were evaluated that were medically recorded in prenatal maternity logbooks during the critical period of IOA. Results: The findings of this case\u2013control study suggested that the mothers of cases with IOA had a higher proportion of first delivery and lower socioeconomic status. Acute respiratory diseases (odds ratio [OR] 95% confidence interval [CI], 3.8, 1.8\u20138.1) and essential hypertension treated with nifedipine (OR 95% CI, 3.8, 1.7\u20138.7) in the mothers of cases associated with a higher risk for IOA in their children. Conclusion: First delivery, lower socioeconomic status, acute respiratory diseases and essential hypertension treated with nifedipine in the mothers may associate with a higher risk for IOA in their children. Birth Defects Research (Part A) 103:804\u2013813, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bdra.23383","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T17:59:03Z","timestamp":1432835943000},"page":"804-813","source":"Crossref","is-referenced-by-count":11,"title":["Maternal factors in the origin of isolated oesophageal atresia: A population\u2010based case\u2013control study"],"prefix":"10.1002","volume":"103","author":[{"given":"G\u00e1bor","family":"Vermes","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Military Hospital \u2013 State Health Centre Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"M\u00e1trai","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Czeizel","sequence":"additional","affiliation":[{"name":"Foundation for the Community Control of Hereditary Diseases Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.227"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182a373dc"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2003.00283.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartasia-2013-010331"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960315)62:2<179::AID-AJMG12>3.0.CO;2-L"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199705)55:5<299::AID-TERA1>3.0.CO;2-V"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2008.00189.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740330902916459"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441773"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.02.018"},{"key":"e_1_2_5_13_1","first-page":"299","article-title":"Birth prevalence of five congenital abnormalities of medium frequency in Budapest","volume":"22","author":"Czeizel AE","year":"1981","journal-title":"Acta Paediatr Acad Sci Hung"},{"key":"e_1_2_5_14_1","volume-title":"Multiple congenital abnormalities","author":"Czeizel AE","year":"1988"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6876.499"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1032"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.766"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20086"},{"key":"e_1_2_5_19_1","first-page":"179","article-title":"Smoking and alcohol drinking during pregnancy. 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