{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:20:50Z","timestamp":1740136850707,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T00:00:00Z","timestamp":1439769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81273164"],"award-info":[{"award-number":["81273164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Dental & Cranial Facial Research","award":["R21-DE-013707","R01-DE-014581"],"award-info":[{"award-number":["R21-DE-013707","R01-DE-014581"]}]},{"name":"Fogarty Institution","award":["D43-TW006176"],"award-info":[{"award-number":["D43-TW006176"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The forkhead box F2 gene (<jats:italic>FOXF2<\/jats:italic>) located in chromosome 6p25.3 has been shown to play a crucial role in palatal development in mouse and rat models. To date, no evidence of linkage or association has been reported for this gene in humans with oral clefts.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Allelic transmission disequilibrium tests were used to robustly assess evidence of linkage and association with nonsyndromic cleft lip with or without cleft palate for nine single nucleotide polymorphisms (SNPs) in and around <jats:italic>FOXF2<\/jats:italic> in both Asian and European trios using PLINK.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Statistically significant evidence of linkage and association was shown for two SNPs (<jats:italic>rs1711968<\/jats:italic> and <jats:italic>rs732835<\/jats:italic>) in 216 Asian trios where the empiric <jats:italic>P<\/jats:italic> values with permutation tests were 0.0016 and 0.005, respectively. The corresponding estimated odds ratios for carrying the minor allele at these SNPs were 2.05 (95% confidence interval = 1.41, 2.98) and 1.77 (95% confidence interval = 1.26, 2.49), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our results provided statistical evidence of linkage and association between <jats:italic>FOXF2<\/jats:italic> and nonsyndromic cleft lip with or without cleft palate. Birth Defects Research (Part A) 103:857\u2013862, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23413","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T12:08:10Z","timestamp":1439813290000},"page":"857-862","source":"Crossref","is-referenced-by-count":11,"title":["Novel evidence of association with nonsyndromic cleft lip with or without cleft palate was shown for single nucleotide polymorphisms in <i>FOXF2<\/i> gene in an Asian population"],"prefix":"10.1002","volume":"103","author":[{"given":"Lingxue","family":"Bu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University Beijing China"},{"name":"National Center for Public Health Surveillance and Information Services Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University Beijing China"},{"name":"Ministry of Health KeyLaboratory of Reproductive Health Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Biology and Biomedical Sciences Washington University St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline B.","family":"Hetmanski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Schwender","sequence":"additional","affiliation":[{"name":"Mathematical Institute Heinrich Heine University Duesseldorf Duesseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yah\u2010Huei Wu","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chang Gung Memorial Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Yeow","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery K K Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel S.","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Khoo Teck Puat \u2013 National University Children's Medical Institute, National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Xi'an JiaoTong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethylin Wang","family":"Jabs","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai, New York City, New York, USA. Department of Pediatrics, Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan F.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri H.","family":"Beaty","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200005)218:1<136::AID-DVDY12>3.0.CO;2-U"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.333"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/364412a0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.020"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09534"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000195679"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01577.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005385"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011493"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1839"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.506"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/422475"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000224636"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090711-163729"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2144\/jun0207"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_6_21_1","first-page":"506","article-title":"Transmission test for linkage disequilibrium: the insulin gene region and insulin\u2010dependent diabetes mellitus (IDDM)","volume":"52","author":"Spielman RS","year":"1993","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00176-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01588.x"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23413","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T01:59:58Z","timestamp":1696643998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,17]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/bdra.23413"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23413","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"type":"print","value":"1542-0752"},{"type":"electronic","value":"1542-0760"}],"subject":[],"published":{"date-parts":[[2015,8,17]]}}}