{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:49:10Z","timestamp":1792259350352,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fetal exposure to maternal ingestion of warfarin is known to produce certain dysmorphic features in the neonate, known as fetal warfarin syndrome (FWS). There is a general consensus that maternal intake of warfarin at a daily dose of 5\u2009mg or less is safe both for the infant and the mother.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report four cases of FWS born to mothers with rheumatic heart disease on warfarin prophylaxis during pregnancy at a dose less than 5\u2009mg\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Along with typical facial features of FWS and multiple epiphyseal stippling in skeletal x\u2010ray, Case 1 had Dandy\u2010Walker malformation and Case 2 had laryngo\u2010tracheomalacia and patent ductus arteriosus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We emphasize the need for optimizing the choice and dosage schedule of anticoagulants during pregnancy, least harmful for the mother and her developing fetus. Birth Defects Research (Part A) 106:142\u2013147, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23435","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T12:55:10Z","timestamp":1442840110000},"page":"142-147","source":"Crossref","is-referenced-by-count":37,"title":["Low\u2010dose maternal warfarin intake resulting in fetal warfarin syndrome: In search for a safe anticoagulant regimen during pregnancy"],"prefix":"10.1002","volume":"106","author":[{"given":"Sriparna","family":"Basu","sequence":"first","affiliation":[{"name":"Neonatology Unit, Department of Pediatrics, Institute of Medical Sciences Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Department of Pediatrics, Institute of Medical Sciences Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Kakani","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Department of Pediatrics, Institute of Medical Sciences Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Department of Pediatrics, Institute of Medical Sciences Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2300"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0761"},{"key":"e_1_2_5_4_1","first-page":"731","volume-title":"Birth defects encyclopedia","author":"Hall JG","year":"1990"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu009"},{"key":"e_1_2_5_6_1","first-page":"691","article-title":"Fetal warfarin syndrome","volume":"27","author":"Hou JW","year":"2004","journal-title":"Chang Gung Med J"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.883947"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/021849230701500609"},{"key":"e_1_2_5_9_1","first-page":"47","article-title":"Anti\u2010coagulation during pregnancy in women with mechanical heart valves: a prospective study","volume":"5","author":"Khamoushi AJ","year":"2011","journal-title":"Int J Fertil Steril"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.12.2011.5291"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2012-022"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(11)70016-0"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971017)72:2<129::AID-AJMG2>3.0.CO;2-Q"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-1-59"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"e448","DOI":"10.18295\/2075-0528.1617","article-title":"Mechanical prosthetic valves and pregnancy: a therapeutic dilemma of anticoagulation","volume":"14","author":"Panduranga P","year":"2014","journal-title":"Sultan Qaboos Univ Med J"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36655"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.09.011"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23435","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T18:48:02Z","timestamp":1748630882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,21]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/bdra.23435"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23435","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,21]]}}}