{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:01:54Z","timestamp":1792101714603,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["HD051880"],"award-info":[{"award-number":["HD051880"]}]},{"DOI":"10.13039\/100000073","name":"Autism Speaks","doi-asserted-by":"crossref","award":["8202"],"award-info":[{"award-number":["8202"]}],"id":[{"id":"10.13039\/100000073","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Folate receptor autoantibodies in women have been associated with neural tube pregnancy and in children with cerebral folate deficiency syndrome and autism. These autoantibodies have been implicated in blocking folate transport to the fetus and to the brain in infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a woman with multiple pregnancy related complications who was diagnosed with autoantibodies to the folate receptor alpha.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A treatment strategy with folate supplementation and reducing the antibody titer proved effective in normal pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This long\u2010term follow up of a subject with folate receptor autoantibodies is a first report of its kind and describes treatment strategy to prevent pregnancy related complications due to folate receptor autoantibodies. Birth Defects Research (Part A) 103:1028\u20131030, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23436","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T12:55:07Z","timestamp":1442840107000},"page":"1028-1030","source":"Crossref","is-referenced-by-count":19,"title":["Folate receptor autoantibodies in pregnancy related complications"],"prefix":"10.1002","volume":"103","author":[{"given":"Iuliana","family":"Shapira","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine SUNY\u2010Downstate Medical Center Brooklyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine SUNY\u2010Downstate Medical Center Brooklyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward V.","family":"Quadros","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine SUNY\u2010Downstate Medical Center Brooklyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.08.104"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2008.08.002"},{"key":"e_1_2_5_4_1","first-page":"1","article-title":"Surveillance for anencephaly and spina bifida and the impact of prenatal diagnosis\u2014 United States, 1985\u20131994","volume":"44","author":"Cragan JD","year":"1995","journal-title":"MMWR CDC Surveill Summ"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.175"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.106335"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.92293"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.02053.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043160"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991148"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1065354"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.22"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031145"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0577"},{"key":"e_1_2_5_16_1","article-title":"The role of folate receptor autoantibodies in preterm birth","author":"Vo HD","year":"2015","journal-title":"Nutrition J [Epub ahead of print]"},{"key":"e_1_2_5_17_1","first-page":"23","volume-title":"Folate in health and disease","author":"Wagner C","year":"1995"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23436","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:58:57Z","timestamp":1696625937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,21]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/bdra.23436"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23436","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"value":"1542-0752","type":"print"},{"value":"1542-0760","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,21]]}}}