{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T03:09:59Z","timestamp":1696648199929},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acardiac twinning is a rare anomaly of monochorionic twin pregnancies. Acardiac fetuses lack a functional heart but are passively perfused by arterial blood from their pump co\u2010twin. Although four acardiac morphological types have been classified, the various paths of anatomical and circulatory acardiac twin development, and the potential influence of acardiac size and perfusion flow as possible predictors of pump twin morbidity and mortality are poorly understood. This report presents the first high resolution three\u2010dimensional reconstruction of the vasculature of an acardiac twin by cryomicrotome imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A small, approximately 7.5\u2010cm\u2010diameter ball\u2010shaped acardius amorphous of 30 5\/7 weeks had caused pump twin cardiac decompensation that necessitated an emergency cesarian section. The pump twin survived well. The acardiac body had a partially intact vascular system with large diameter arteries and veins and multiple zones that appeared devoid of perfusion. The three\u2010dimensional reconstruction showed neither recognizable organ structures nor identifiable blood vessels except for the umbilical artery and vein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our case showed a small acardiac mass with large diameter vessels and consequential low outflow resistance that caused pump twin complications. This indicates that the development of a method that allows pump twin prognosis is likely more successful if based on the use of acardiac versus pump twin perfusion flows than on body volume ratios. Birth Defects Research (Part A) 106:213\u2013217, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23477","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T14:10:46Z","timestamp":1450707046000},"page":"213-217","source":"Crossref","is-referenced-by-count":6,"title":["Acardiac twinning: High resolution three\u2010dimensional reconstruction of a low resistance case"],"prefix":"10.1002","volume":"106","author":[{"given":"Monique G.J.T.B.","family":"van Lier","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Physics Academic Medical Center\u2010University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Leiden University Medical Center Leiden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank P.H.A.","family":"Vandenbussche","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center Leiden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert J.","family":"Streekstra","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics Academic Medical Center\u2010University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Siebes","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics Academic Medical Center\u2010University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.J.","family":"Nikkels","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Center and Wilhelmina Children's Hospital  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center Leiden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.C.","family":"van Gemert","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics Academic Medical Center\u2010University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen P.H.M.","family":"van den Wijngaard","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics Academic Medical Center\u2010University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Clinical Chemistry and Laboratory Medicine Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.08.009"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2008.27.7.1105"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00404-4"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050105"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20296"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1902.tb15905.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.113906"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-002-1002-0"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1389.023"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-005-1454-2"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420500306"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39586"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91094-S"},{"key":"e_1_2_4_15_1","first-page":"472","article-title":"Prenatal sonographic diagnosis. 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