{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T12:21:39Z","timestamp":1707308499645},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Gastroschisis is the most common abdominal wall defect. It is characterized by herniation of the intestine and other abdominal organs through a defect in the abdominal wall. Neuroblastoma is the most common malignant tumor observed during the neonatal period. It is a neuroendocrine tumor derived from neural crest cells that develops into the adrenal gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We report on the undescribed association between gastrochisis and congenital neuroblastoma, diagnosised during the prenatal period. The mother was a 20\u2010year\u2010old healthy pregnant woman in her second pregnancy. Obstetric ultrasound examination showed a fetus presenting an abdominal wall defect on the right side of the umbilical cord, compatible with gastroschisis, and a hyperechogenic and spherical solid lesion on the left adrenal gland. Fetal magnetic resonance imaging disclosed similar features associated to a heterogeneous aspect of the liver. The diagnosis of metastatic neuroblastoma was confirmed after birth through liver biopsy. At 2 days of life, the prothrombrin time was abnormal, and the patient needed vitamin K.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We cannot rule out the possibility that a clotting defect, commonly observed in disseminated malignancies such as a metastatic neuroblastoma may be associated with the etiology of the gastroschisis, as this defect may result from a thrombosis occurring around 3 to 4 weeks of gestation, a period when neuroblasts development occurs into the adrenal medulla. However, we cannot exclude the possibility that both events may have occurred simultaneously by chance. Birth Defects Research (Part A) 106:208\u2013212, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23484","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T07:23:25Z","timestamp":1455521005000},"page":"208-212","source":"Crossref","is-referenced-by-count":1,"title":["Gastroschisis in a fetus with a congenital neuroblastoma: Association or coincidence?"],"prefix":"10.1002","volume":"106","author":[{"given":"Rafael F.M.","family":"Rosa","sequence":"first","affiliation":[{"name":"Clinical Genetics Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) and Complexo Hospitalar Santa Casa de Porto Alegre (CHSCPA)  RS Brazil"},{"name":"Clinical Genetics Hospital Materno Infantil Presidente Vargas (HMIPV)  RS Brazil"},{"name":"Graduate Program in Pathology UFCSPA  RS Brazil"},{"name":"Fetal Medicine HMIPV  RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Michelon","sequence":"additional","affiliation":[{"name":"Graduation in Medicine Universidade Luterana do Brasil (ULBRA)  RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1tila","family":"Masiero","sequence":"additional","affiliation":[{"name":"Graduation in Medicine Universidade Luterana do Brasil (ULBRA)  RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adyr E.V.","family":"Faria","sequence":"additional","affiliation":[{"name":"Pediatric Surgery HMIPV  RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa F. 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