{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:44:10Z","timestamp":1762101850234,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pilot Project Funding","award":["2T42OH008421"],"award-info":[{"award-number":["2T42OH008421"]}]},{"name":"National Institute for Occupational Safety and Health (NIOSH)\/Centers for Disease Control and Prevention","award":["R03 grant"],"award-info":[{"award-number":["R03 grant"]}]},{"DOI":"10.13039\/100000125","name":"NIOSH","doi-asserted-by":"crossref","award":["R03OH010315"],"award-info":[{"award-number":["R03OH010315"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>An increasing number of radiologic exams are performed in the United States, but very few studies have examined the effects of maternal exposure to radiologic exams during the periconceptional period and birth defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the association between maternal exposure to radiologic exams during the periconceptional period and 19 categories of birth defects using a large population\u2010based study of birth defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 27,809 case mothers and 10,200 control mothers who participated in the National Birth Defects Prevention Study and delivered between 1997 and 2009. Maternal exposure to radiologic exams that delivered ionizing radiation to the urinary tract, lumbar spine, abdomen, or pelvis were identified based on the mother's report of type of radiologic exams, organ or body part scanned and the month during which the exam occurred<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 0.9% of mothers reported exposure to one of these types of radiographic exams during the periconceptional period. We observed significant associations between maternal exposure during the first trimester and isolated Dandy\u2010Walker malformation (odds ratio = 7.7; 95% confidence interval, 1.8\u201333) and isolated d\u2010transposition of the great arteries (odds ratio = 3.8; 95% confidence interval, 1.4\u201310.3). However, the result for isolated Dandy\u2010Walker malformation was based on only two exposed cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results should be interpreted cautiously because multiple statistical tests were conducted and measurements of exposure were based on maternal report. However, our results may be useful for generating hypotheses for future studies. Birth Defects Research (Part A) 106:563\u2013572, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdra.23496","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T10:55:15Z","timestamp":1458644115000},"page":"563-572","source":"Crossref","is-referenced-by-count":3,"title":["Maternal exposure to radiographic exams and major structural birth defects"],"prefix":"10.1002","volume":"106","author":[{"given":"Hyeyeun","family":"Lim","sequence":"first","affiliation":[{"name":"University of Texas School of Public Health Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles W.","family":"Beasley","sequence":"additional","affiliation":[{"name":"University of Texas School of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence W.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"University of Texas School of Public Health Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Emery","sequence":"additional","affiliation":[{"name":"University of Texas School of Public Health Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Agopian","sequence":"additional","affiliation":[{"name":"University of Texas School of Public Health Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Langlois","sequence":"additional","affiliation":[{"name":"Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy K.","family":"Waller","sequence":"additional","affiliation":[{"name":"University of Texas School of Public Health Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the National Birth Defects Prevention Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,22]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Agency for Toxic Substances & Disease Registry.1999. Public health statement for ionizing radiation. Available at:http:\/\/www.atsdr.cdc.gov\/phs\/phs.asp?id=482&tid=86. Accessed September 1 2015."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2491071665"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20403"},{"key":"e_1_2_6_5_1","unstructured":"Centers for Disease Control Prevention.Radiation and pregnancy: a fact sheet for clinicians. Available at:http:\/\/www.bt.cdc.gov\/radiation\/prenatalphysician.asp. Accessed September 1 2015."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318180a505"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12043"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200098"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.04.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901249"},{"volume-title":"Epidemiology of congenital heart disease: The Baltimore\u2010Washington Infant Study 1981\u20131989","year":"1993","author":"Ferencz C","key":"e_1_2_6_11_1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-69-824-751"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/1.1.113"},{"volume-title":"Fact sheet: Radiation exposure from medical exams and procedures","year":"2010","author":"Health Physics Society Specialists in Radiation Safety","key":"e_1_2_6_14_1"},{"volume-title":"Health risks from exposure to low levels of ionizing radiation: BEIR VII","year":"2006","key":"e_1_2_6_15_1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2009.048256"},{"volume-title":"Pregnancy and medical radiation","year":"2000","author":"International Commission on Radiological Protection (ICRP)","key":"e_1_2_6_17_1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(84)90034-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2512080736"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2004.00212.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061404598"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.274065149"},{"volume-title":"Report no. 160 Ionizing radiation exposure of the population of the United States","year":"2009","author":"National Council on Radiation Radiation Protection and Measurements","key":"e_1_2_6_23_1"},{"volume-title":"Report no. 171 Uncertainties in the estimation of radiation risks and probability of disease causation","year":"2012","author":"National Council on Radiation Protection and Measurements","key":"e_1_2_6_24_1"},{"key":"e_1_2_6_25_1","unstructured":"National Institute for Occupational Safety and Health.Workplace safety and health topics. Available at:http:\/\/Www.cdc.gov\/niosh\/topics\/. Accessed September 1 2015."},{"key":"e_1_2_6_26_1","first-page":"318425","article-title":"Foetal radiation dose and risk from diagnostic radiology procedures: a multinational study","volume":"2013","author":"Osei EK","year":"2012","journal-title":"ISRN Radiol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10012"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4103\/0971-6203.49883","article-title":"Evolution of radiation dose and risk during hysteroslapingography examinations performed using digital imaging system","volume":"28","author":"Roshan S","year":"2003","journal-title":"J Med Phys"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-199711000-00003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncm324"},{"key":"e_1_2_6_31_1","unstructured":"The Agency for Clinical Innovation.2015.Radiology clinician fact sheet. Available at:http:\/\/www.aci.health.nsw.gov.au\/__data\/assets\/pdf_file\/0006\/174552\/MI\u2010Clinician\u2010Factsheet.pdf. Accessed September 1 2015"},{"volume-title":"Radiation risk of medical imaging during pregnancy","year":"2011","author":"Wallace A","key":"e_1_2_6_32_1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2008.05.012"},{"key":"e_1_2_6_34_1","first-page":"282","article-title":"Radionuclide hysterosalpingography with technetium\u201099m\u2010pertechnetate: application and radiation dose to the ovaries","volume":"33","author":"Yang KT","year":"1992","journal-title":"J Nucl Med"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/phr\/116.S1.32"}],"container-title":["Birth Defects Research Part A: Clinical and Molecular Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdra.23496","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdra.23496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T10:02:15Z","timestamp":1696586535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdra.23496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,22]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/bdra.23496"],"URL":"https:\/\/doi.org\/10.1002\/bdra.23496","archive":["Portico"],"relation":{},"ISSN":["1542-0752","1542-0760"],"issn-type":[{"type":"print","value":"1542-0752"},{"type":"electronic","value":"1542-0760"}],"subject":[],"published":{"date-parts":[[2016,3,22]]}}}